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000016159 0247_ $$2DOI$$a10.1016/j.neuroimage.2011.07.022
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000016159 041__ $$aeng
000016159 082__ $$a610
000016159 084__ $$2WoS$$aNeurosciences
000016159 084__ $$2WoS$$aNeuroimaging
000016159 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000016159 1001_ $$0P:(DE-HGF)0$$aFriebel, U.$$b0
000016159 245__ $$aCoordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain
000016159 260__ $$aOrlando, Fla.$$bAcademic Press$$c2011
000016159 300__ $$a1070–1080
000016159 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000016159 3367_ $$2BibTeX$$aARTICLE
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000016159 440_0 $$04545$$aNeuroImage$$v58$$x1053-8119$$y1070 - 1080
000016159 500__ $$aWe would like to thank Dr. A. Kaza for help with the establishment of the ALE software. We also want to thank Flavia Di Pietro (Neura, Sydney, Australia) for going through the last version of the manuscript and eliminate language problems. This study was supported by funding from the Human Brain Project of the National Institute of Mental Health (R01-MH074457-01A1) and the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model). An exchange grand from the DFG (LO 795/10-1) was provided to M.L.
000016159 520__ $$aDifferences in brain activation in experimentally induced and chronic neuropathic pain conditions are useful for understanding central mechanisms leading to chronic neuropathic pain. Many mapping studies investigating both pain conditions are now available, and the latest tools for coordinate-based meta-analysis offer the possibility of random effects statistics. We performed a meta-analysis based on a literature search of published functional magnetic resonance imaging group studies to compare patterns of activity during experimentally induced and chronic neuropathic pain, for the later including four fibromyalgia studies. Stimulus-dependent activation in experimental pain was further divided into "thermal" and "non thermal" stimuli. A conjunction of experimentally induced and chronic neuropathic pain revealed activation of the bilateral secondary somatosensory cortex, right middle cingulate cortex, right inferior parietal lobe, supplementary motor area, right caudal anterior insula, and bilateral thalamus. Primary somatosensory activation was only observed during experimental non-thermal stimulation. Chronic neuropathic pain studies showed increased activation in the left secondary somatosensory cortex, anterior cingulate cortex, and right caudal anterior insula when compared to experimentally induced pain. Activation clusters in the anterior cingulate cortex and caudal anterior insula suggest a strong emotional contribution to the processing of chronic neuropathic pain.
000016159 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
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000016159 588__ $$aDataset connected to Web of Science, Pubmed
000016159 65320 $$2Author$$aExperimental pain
000016159 65320 $$2Author$$aChronic neuropathic pain
000016159 65320 $$2Author$$aMeta-analysis
000016159 65320 $$2Author$$aImaging
000016159 65320 $$2Author$$afMRI
000016159 650_2 $$2MeSH$$aBrain: physiopathology
000016159 650_2 $$2MeSH$$aCerebral Cortex: physiopathology
000016159 650_2 $$2MeSH$$aCluster Analysis
000016159 650_2 $$2MeSH$$aFrontal Lobe: physiopathology
000016159 650_2 $$2MeSH$$aHot Temperature: diagnostic use
000016159 650_2 $$2MeSH$$aHumans
000016159 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000016159 650_2 $$2MeSH$$aNeural Pathways: physiopathology
000016159 650_2 $$2MeSH$$aNeuralgia: physiopathology
000016159 650_2 $$2MeSH$$aNeuralgia: psychology
000016159 650_2 $$2MeSH$$aPain Measurement
000016159 650_2 $$2MeSH$$aPain Perception: physiology
000016159 650_2 $$2MeSH$$aPhysical Stimulation
000016159 650_2 $$2MeSH$$aPrefrontal Cortex: physiopathology
000016159 650_2 $$2MeSH$$aSomatosensory Cortex: physiopathology
000016159 650_7 $$2WoSType$$aJ
000016159 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b1$$uFZJ
000016159 7001_ $$0P:(DE-HGF)0$$aLotze, M.$$b2
000016159 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2011.07.022$$gVol. 58$$p1070–1080$$q58$$tNeuroImage$$v58$$x1053-8119$$y2011
000016159 8567_ $$uhttp://dx.doi.org/10.1016/j.neuroimage.2011.07.022
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000016159 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000016159 9141_ $$y2011
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