Journal Article

PreJuSER-16159

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain

Friebel, U. ; Eickhoff, S. B.FZJ* ; Lotze, M.

2011
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.neuroimage.2011.07.022

Abstract: Differences in brain activation in experimentally induced and chronic neuropathic pain conditions are useful for understanding central mechanisms leading to chronic neuropathic pain. Many mapping studies investigating both pain conditions are now available, and the latest tools for coordinate-based meta-analysis offer the possibility of random effects statistics. We performed a meta-analysis based on a literature search of published functional magnetic resonance imaging group studies to compare patterns of activity during experimentally induced and chronic neuropathic pain, for the later including four fibromyalgia studies. Stimulus-dependent activation in experimental pain was further divided into "thermal" and "non thermal" stimuli. A conjunction of experimentally induced and chronic neuropathic pain revealed activation of the bilateral secondary somatosensory cortex, right middle cingulate cortex, right inferior parietal lobe, supplementary motor area, right caudal anterior insula, and bilateral thalamus. Primary somatosensory activation was only observed during experimental non-thermal stimulation. Chronic neuropathic pain studies showed increased activation in the left secondary somatosensory cortex, anterior cingulate cortex, and right caudal anterior insula when compared to experimentally induced pain. Activation clusters in the anterior cingulate cortex and caudal anterior insula suggest a strong emotional contribution to the processing of chronic neuropathic pain.

Keyword(s): Brain: physiopathology (MeSH) ; Cerebral Cortex: physiopathology (MeSH) ; Cluster Analysis (MeSH) ; Frontal Lobe: physiopathology (MeSH) ; Hot Temperature: diagnostic use (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Neural Pathways: physiopathology (MeSH) ; Neuralgia: physiopathology (MeSH) ; Neuralgia: psychology (MeSH) ; Pain Measurement (MeSH) ; Pain Perception: physiology (MeSH) ; Physical Stimulation (MeSH) ; Prefrontal Cortex: physiopathology (MeSH) ; Somatosensory Cortex: physiopathology (MeSH) ; J ; Experimental pain (auto) ; Chronic neuropathic pain (auto) ; Meta-analysis (auto) ; Imaging (auto) ; fMRI (auto)

Note: We would like to thank Dr. A. Kaza for help with the establishment of the ALE software. We also want to thank Flavia Di Pietro (Neura, Sydney, Australia) for going through the last version of the manuscript and eliminate language problems. This study was supported by funding from the Human Brain Project of the National Institute of Mental Health (R01-MH074457-01A1) and the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model). An exchange grand from the DFG (LO 795/10-1) was provided to M.L.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)

Appears in the scientific report 2011

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