TY  - JOUR
AU  - Friebel, U.
AU  - Eickhoff, S.B.
AU  - Lotze, M.
TI  - Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain
JO  - NeuroImage
VL  - 58
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - PreJuSER-16159
SP  - 1070–1080
PY  - 2011
N1  - We would like to thank Dr. A. Kaza for help with the establishment of the ALE software. We also want to thank Flavia Di Pietro (Neura, Sydney, Australia) for going through the last version of the manuscript and eliminate language problems. This study was supported by funding from the Human Brain Project of the National Institute of Mental Health (R01-MH074457-01A1) and the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model). An exchange grand from the DFG (LO 795/10-1) was provided to M.L.
AB  - Differences in brain activation in experimentally induced and chronic neuropathic pain conditions are useful for understanding central mechanisms leading to chronic neuropathic pain. Many mapping studies investigating both pain conditions are now available, and the latest tools for coordinate-based meta-analysis offer the possibility of random effects statistics. We performed a meta-analysis based on a literature search of published functional magnetic resonance imaging group studies to compare patterns of activity during experimentally induced and chronic neuropathic pain, for the later including four fibromyalgia studies. Stimulus-dependent activation in experimental pain was further divided into "thermal" and "non thermal" stimuli. A conjunction of experimentally induced and chronic neuropathic pain revealed activation of the bilateral secondary somatosensory cortex, right middle cingulate cortex, right inferior parietal lobe, supplementary motor area, right caudal anterior insula, and bilateral thalamus. Primary somatosensory activation was only observed during experimental non-thermal stimulation. Chronic neuropathic pain studies showed increased activation in the left secondary somatosensory cortex, anterior cingulate cortex, and right caudal anterior insula when compared to experimentally induced pain. Activation clusters in the anterior cingulate cortex and caudal anterior insula suggest a strong emotional contribution to the processing of chronic neuropathic pain.
KW  - Brain: physiopathology
KW  - Cerebral Cortex: physiopathology
KW  - Cluster Analysis
KW  - Frontal Lobe: physiopathology
KW  - Hot Temperature: diagnostic use
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Neural Pathways: physiopathology
KW  - Neuralgia: physiopathology
KW  - Neuralgia: psychology
KW  - Pain Measurement
KW  - Pain Perception: physiology
KW  - Physical Stimulation
KW  - Prefrontal Cortex: physiopathology
KW  - Somatosensory Cortex: physiopathology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21798355
UR  - <Go to ISI:>//WOS:000295183200011
DO  - DOI:10.1016/j.neuroimage.2011.07.022
UR  - https://juser.fz-juelich.de/record/16159
ER  -