%0 Journal Article
%A Wendland, F.
%A Berthold, G.
%A Fritsche, J.-G.
%A Herrmann, F.
%A Kunkel, R.
%A Voigt, H.-J.
%A Vereecken, H.
%T A conceptual hydrogeological model for evaluating residence times in Hessen
%J Grundwasser
%V 16
%@ 1430-483X
%C Berlin
%I Springer
%M PreJuSER-17016
%P 163 - 176
%D 2011
%Z Record converted from VDB: 12.11.2012
%X The association between long-term use of depot-medroxyprogesterone acetate (DMPA) and bone mineral density (BMD) has been controversial, as seen in three case-control studies in New Zealand, Thailand, and the United Kingdom. In the present case-controlled study of BMD, a group of 67 Chinese women who had used DMPA from 5-15 years was compared with 218 women of the same age range who had not used any steroidal hormones. DMPA users were found to have a significantly lower BMD at lumbar vertebra (L2-4) (0.93 g/cm2), neck of femur (0.69 g/cm2), trochanter (0.59 g/cm2), and Ward's triangle (0.58 g/cm2), as compared with the control group, whose corresponding BMD values were 1.03 g/cm2, 0.83 g/cm2, 0.71 g/cm2, and 0.78 g/cm2, respectively (p < 0.001). The average percentage of bone loss per year was estimated to be 1.1% in L2-4, 2.3% in neck of femur, 2.4% in trochanter, and 3.5% in Ward's triangle. The percentage of bone loss in L2-4 was found to be more pronounced with age. This study provided information that the use of DMPA in a Chinese group for > 5 years in associated with bone loss, and a prospective study is needed to confirm these data, which are different from two case-control studies.
%K Absorptiometry, Photon
%K Adult
%K Age Factors
%K Amenorrhea
%K Body Mass Index
%K Bone Density: drug effects
%K Bone Resorption: etiology
%K Calcium: metabolism
%K Case-Control Studies
%K China
%K Contraceptive Agents, Female: pharmacology
%K Female
%K Femur: physiopathology
%K Humans
%K Lumbar Vertebrae: physiopathology
%K Medroxyprogesterone Acetate: pharmacology
%K Middle Aged
%K Questionnaires
%K Regression Analysis
%K Contraceptive Agents, Female (NLM Chemicals)
%K Medroxyprogesterone Acetate (NLM Chemicals)
%K Calcium (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:10342083
%U <Go to ISI:>//WOS:000294471600004
%R 10.1007/s00767-011-0169-6
%U https://juser.fz-juelich.de/record/17016