Journal Article

PreJuSER-17016

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A conceptual hydrogeological model for evaluating residence times in Hessen

Wendland, F.FZJ* ; Berthold, G. ; Fritsche, J.-G. ; Herrmann, F.FZJ* ; Kunkel, R.FZJ* ; Voigt, H.-J. ; Vereecken, H.FZJ*

2011
Springer Berlin

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Please use a persistent id in citations: doi:10.1007/s00767-011-0169-6

Abstract: The association between long-term use of depot-medroxyprogesterone acetate (DMPA) and bone mineral density (BMD) has been controversial, as seen in three case-control studies in New Zealand, Thailand, and the United Kingdom. In the present case-controlled study of BMD, a group of 67 Chinese women who had used DMPA from 5-15 years was compared with 218 women of the same age range who had not used any steroidal hormones. DMPA users were found to have a significantly lower BMD at lumbar vertebra (L2-4) (0.93 g/cm2), neck of femur (0.69 g/cm2), trochanter (0.59 g/cm2), and Ward's triangle (0.58 g/cm2), as compared with the control group, whose corresponding BMD values were 1.03 g/cm2, 0.83 g/cm2, 0.71 g/cm2, and 0.78 g/cm2, respectively (p < 0.001). The average percentage of bone loss per year was estimated to be 1.1% in L2-4, 2.3% in neck of femur, 2.4% in trochanter, and 3.5% in Ward's triangle. The percentage of bone loss in L2-4 was found to be more pronounced with age. This study provided information that the use of DMPA in a Chinese group for > 5 years in associated with bone loss, and a prospective study is needed to confirm these data, which are different from two case-control studies.

Keyword(s): Absorptiometry, Photon (MeSH) ; Adult (MeSH) ; Age Factors (MeSH) ; Amenorrhea (MeSH) ; Body Mass Index (MeSH) ; Bone Density: drug effects (MeSH) ; Bone Resorption: etiology (MeSH) ; Calcium: metabolism (MeSH) ; Case-Control Studies (MeSH) ; China (MeSH) ; Contraceptive Agents, Female: pharmacology (MeSH) ; Female (MeSH) ; Femur: physiopathology (MeSH) ; Humans (MeSH) ; Lumbar Vertebrae: physiopathology (MeSH) ; Medroxyprogesterone Acetate: pharmacology (MeSH) ; Middle Aged (MeSH) ; Questionnaires (MeSH) ; Regression Analysis (MeSH) ; Contraceptive Agents, Female ; Medroxyprogesterone Acetate ; Calcium ; J ; Conceptual hydrogeological model (auto) ; Residence times (auto) ; EU-WFD (auto) ; Large-scale model (auto) ; Hessen (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Agrosphäre (IBG-3)

Research Program(s):

1. Terrestrische Umwelt (P24)

Appears in the scientific report 2011

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