TY  - JOUR
AU  - Wendland, F.
AU  - Berthold, G.
AU  - Fritsche, J.-G.
AU  - Herrmann, F.
AU  - Kunkel, R.
AU  - Voigt, H.-J.
AU  - Vereecken, H.
TI  - A conceptual hydrogeological model for evaluating residence times in Hessen
JO  - Grundwasser
VL  - 16
SN  - 1430-483X
CY  - Berlin
PB  - Springer
M1  - PreJuSER-17016
SP  - 163 - 176
PY  - 2011
N1  - Record converted from VDB: 12.11.2012
AB  - The association between long-term use of depot-medroxyprogesterone acetate (DMPA) and bone mineral density (BMD) has been controversial, as seen in three case-control studies in New Zealand, Thailand, and the United Kingdom. In the present case-controlled study of BMD, a group of 67 Chinese women who had used DMPA from 5-15 years was compared with 218 women of the same age range who had not used any steroidal hormones. DMPA users were found to have a significantly lower BMD at lumbar vertebra (L2-4) (0.93 g/cm2), neck of femur (0.69 g/cm2), trochanter (0.59 g/cm2), and Ward's triangle (0.58 g/cm2), as compared with the control group, whose corresponding BMD values were 1.03 g/cm2, 0.83 g/cm2, 0.71 g/cm2, and 0.78 g/cm2, respectively (p < 0.001). The average percentage of bone loss per year was estimated to be 1.1% in L2-4, 2.3% in neck of femur, 2.4% in trochanter, and 3.5% in Ward's triangle. The percentage of bone loss in L2-4 was found to be more pronounced with age. This study provided information that the use of DMPA in a Chinese group for > 5 years in associated with bone loss, and a prospective study is needed to confirm these data, which are different from two case-control studies.
KW  - Absorptiometry, Photon
KW  - Adult
KW  - Age Factors
KW  - Amenorrhea
KW  - Body Mass Index
KW  - Bone Density: drug effects
KW  - Bone Resorption: etiology
KW  - Calcium: metabolism
KW  - Case-Control Studies
KW  - China
KW  - Contraceptive Agents, Female: pharmacology
KW  - Female
KW  - Femur: physiopathology
KW  - Humans
KW  - Lumbar Vertebrae: physiopathology
KW  - Medroxyprogesterone Acetate: pharmacology
KW  - Middle Aged
KW  - Questionnaires
KW  - Regression Analysis
KW  - Contraceptive Agents, Female (NLM Chemicals)
KW  - Medroxyprogesterone Acetate (NLM Chemicals)
KW  - Calcium (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:10342083
UR  - <Go to ISI:>//WOS:000294471600004
DO  - DOI:10.1007/s00767-011-0169-6
UR  - https://juser.fz-juelich.de/record/17016
ER  -