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000171822 0247_ $$2doi$$a10.1186/scrt500
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000171822 1001_ $$0P:(DE-HGF)0$$aHucklenbroich, J.$$b0$$eCorresponding Author
000171822 245__ $$aAromatic-turmerone induces neural stem cell proliferation in vitro and in vivo.
000171822 260__ $$aLondon$$bBioMed Central$$c2014
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000171822 520__ $$aIntroductionAromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative disease. Furthermore, the effects of ar-turmerone on neural stem cells (NSCs) remain to be investigated.MethodsWe exposed primary fetal rat NSCs to various concentrations of ar-turmerone. Thereafter, cell proliferation and differentiation potential were assessed. In vivo, naïve rats were treated with a single intracerebroventricular (i.c.v.) injection of ar-turmerone. Proliferative activity of endogenous NSCs was assessed in vivo, by using noninvasive positron emission tomography (PET) imaging and the tracer [18F]-fluoro-L-thymidine ([18F]FLT), as well as ex vivo.ResultsIn vitro, ar-turmerone increased dose-dependently the number of cultured NSCs, because of an increase in NSC proliferation (P < 0.01). Proliferation data were supported by qPCR-data for Ki-67 mRNA. In vitro as well as in vivo, ar-turmerone promoted neuronal differentiation of NSCs. In vivo, after i.c.v. injection of ar-turmerone, proliferating NSCs were mobilized from the subventricular zone (SVZ) and the hippocampus of adult rats, as demonstrated by both [18F]FLT-PET and histology (P < 0.05).ConclusionsBoth in vitro and in vivo data suggest that ar-turmerone induces NSC proliferation. Ar-turmerone thus constitutes a promising candidate to support regeneration in neurologic disease.
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000171822 7001_ $$0P:(DE-HGF)0$$aKlein, R.$$b1
000171822 7001_ $$0P:(DE-HGF)0$$aNeumaier, B.$$b2
000171822 7001_ $$0P:(DE-HGF)0$$aGraf, R.$$b3
000171822 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b4$$ufzj
000171822 7001_ $$0P:(DE-HGF)0$$aSchroeter, M.$$b5
000171822 7001_ $$0P:(DE-HGF)0$$aRueger, M. A.$$b6
000171822 773__ $$0PERI:(DE-600)2548671-8$$a10.1186/scrt500$$n4$$pArticle 100 (1-9)$$tStem cell research & therapy$$v5$$x1757-6512$$y2014
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