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@ARTICLE{Hucklenbroich:171822,
      author       = {Hucklenbroich, J. and Klein, R. and Neumaier, B. and Graf,
                      R. and Fink, G. R. and Schroeter, M. and Rueger, M. A.},
      title        = {{A}romatic-turmerone induces neural stem cell proliferation
                      in vitro and in vivo.},
      journal      = {Stem cell research $\&$ therapy},
      volume       = {5},
      number       = {4},
      issn         = {1757-6512},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2014-05381},
      pages        = {Article 100 (1-9)},
      year         = {2014},
      abstract     = {IntroductionAromatic (ar-) turmerone is a major bioactive
                      compound of the herb Curcuma longa. It has been suggested
                      that ar-turmerone inhibits microglia activation, a property
                      that may be useful in treating neurodegenerative disease.
                      Furthermore, the effects of ar-turmerone on neural stem
                      cells (NSCs) remain to be investigated.MethodsWe exposed
                      primary fetal rat NSCs to various concentrations of
                      ar-turmerone. Thereafter, cell proliferation and
                      differentiation potential were assessed. In vivo, naïve
                      rats were treated with a single intracerebroventricular
                      (i.c.v.) injection of ar-turmerone. Proliferative activity
                      of endogenous NSCs was assessed in vivo, by using
                      noninvasive positron emission tomography (PET) imaging and
                      the tracer [18F]-fluoro-L-thymidine ([18F]FLT), as well as
                      ex vivo.ResultsIn vitro, ar-turmerone increased
                      dose-dependently the number of cultured NSCs, because of an
                      increase in NSC proliferation (P < 0.01). Proliferation
                      data were supported by qPCR-data for Ki-67 mRNA. In vitro as
                      well as in vivo, ar-turmerone promoted neuronal
                      differentiation of NSCs. In vivo, after i.c.v. injection of
                      ar-turmerone, proliferating NSCs were mobilized from the
                      subventricular zone (SVZ) and the hippocampus of adult rats,
                      as demonstrated by both [18F]FLT-PET and histology
                      (P < 0.05).ConclusionsBoth in vitro and in vivo data
                      suggest that ar-turmerone induces NSC proliferation.
                      Ar-turmerone thus constitutes a promising candidate to
                      support regeneration in neurologic disease.},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000344567300001},
      pubmed       = {pmid:25928248},
      doi          = {10.1186/scrt500},
      url          = {https://juser.fz-juelich.de/record/171822},
}