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| Home > Publications database > Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. > print |
| 001 | 171822 | ||
| 005 | 20210129214318.0 | ||
| 024 | 7 | _ | |a 10.1186/scrt500 |2 doi |
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| 037 | _ | _ | |a FZJ-2014-05381 |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Hucklenbroich, J. |b 0 |e Corresponding Author |
| 245 | _ | _ | |a Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. |
| 260 | _ | _ | |a London |b BioMed Central |c 2014 |
| 336 | 7 | _ | |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |a Journal Article |b journal |m journal |s 1427812025_6226 |
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| 520 | _ | _ | |a IntroductionAromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative disease. Furthermore, the effects of ar-turmerone on neural stem cells (NSCs) remain to be investigated.MethodsWe exposed primary fetal rat NSCs to various concentrations of ar-turmerone. Thereafter, cell proliferation and differentiation potential were assessed. In vivo, naïve rats were treated with a single intracerebroventricular (i.c.v.) injection of ar-turmerone. Proliferative activity of endogenous NSCs was assessed in vivo, by using noninvasive positron emission tomography (PET) imaging and the tracer [18F]-fluoro-L-thymidine ([18F]FLT), as well as ex vivo.ResultsIn vitro, ar-turmerone increased dose-dependently the number of cultured NSCs, because of an increase in NSC proliferation (P < 0.01). Proliferation data were supported by qPCR-data for Ki-67 mRNA. In vitro as well as in vivo, ar-turmerone promoted neuronal differentiation of NSCs. In vivo, after i.c.v. injection of ar-turmerone, proliferating NSCs were mobilized from the subventricular zone (SVZ) and the hippocampus of adult rats, as demonstrated by both [18F]FLT-PET and histology (P < 0.05).ConclusionsBoth in vitro and in vivo data suggest that ar-turmerone induces NSC proliferation. Ar-turmerone thus constitutes a promising candidate to support regeneration in neurologic disease. |
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| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Klein, R. |b 1 |
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| 773 | _ | _ | |0 PERI:(DE-600)2548671-8 |a 10.1186/scrt500 |n 4 |p Article 100 (1-9) |t Stem cell research & therapy |v 5 |x 1757-6512 |y 2014 |
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