Subspecialization in the human posterior medial cortex

Bzdok, Danilo; Zilles, Karl; Vogt, Brent A.; Heeger, Adrian; Laird, Angela R.; Langner, Robert; Fox, Peter T.; Eickhoff, Simon; Palomero-Gallagher, Nicola

doi:10.1016/j.neuroimage.2014.11.009

Journal Article

FZJ-2014-05901

Subspecialization in the human posterior medial cortex

Bzdok, D.FZJ* ; Heeger, A. ; Langner, R.FZJ* ; Laird, A. R. ; Fox, P. T. ; Palomero-Gallagher, N.FZJ* ; Vogt, B. A.FZJ* ; Zilles, K.FZJ* ; Eickhoff, S. (Corresponding Author)FZJ*

2015
Academic Press Orlando, Fla.

NeuroImage 106, 55–71 (2015) [10.1016/j.neuroimage.2014.11.009]

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Please use a persistent id in citations: doi:10.1016/j.neuroimage.2014.11.009

Abstract: The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach. First, we subdivided the PMC by whole-brain coactivation profiles. Second, functional connectivity of the ensuing PMC regions was compared by task-constrained meta-analytic coactivation mapping (MACM) and task-unconstrained resting-state correlations (RSFC). Third, PMC regions were functionally described by forward/reverse functional inference. A precuneal cluster was mostly connected to the intraparietal sulcus, frontal eye fields, and right temporo-parietal junction; associated with attention and motor tasks. A ventral posterior cingulate cortex (PCC) cluster was mostly connected to the ventromedial prefrontal cortex and middle left inferior parietal cortex (IPC); associated with facial appraisal and language tasks. A dorsal PCC cluster was mostly connected to the dorsomedial prefrontal cortex, anterior/posterior IPC, posterior midcingulate cortex, and left dorsolateral prefrontal cortex; associated with delay discounting. A cluster in the retrosplenial cortex was mostly connected to the anterior thalamus and hippocampus. Furthermore, all PMC clusters were congruently coupled with the default mode network according to task-unconstrained but not task-constrained connectivity. We thus identified distinct regions in the PMC and characterized their neural networks and functional implications.

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