Journal Article

FZJ-2014-06286

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Posterior Reversible Encephalopathy Syndrome and Stroke after Intravenous Immunoglobulin Treatment in Miller–Fisher Syndrome/Bickerstaff Brain Stem Encephalitis Overlap Syndrome

Stetefeld, H. R. (Corresponding Author) ; Lehmann, H. C. ; Fink, G. R.FZJ* ; Burghaus, L.

2014
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.jstrokecerebrovasdis.2014.05.034

Abstract: The association of a posterior reversible encephalopathy syndrome (PRES) without arterial hypertension with autoimmune-mediated inflammatory neuropathies such as Guillain–Barré syndrome (GBS) is a rare and poorly understood phenomenon. To date, PRES has been described as initial manifestation, coincidental finding, or adverse event subsequent to immunomodulatory treatment with intravenous immunoglobulin (IVIG) in cases of axonal and demyelinating GBS as well as in Miller–Fisher syndrome (MFS). We here report a case of MFS/Bickerstaff brain stem encephalitis (BBE)–overlap syndrome and nonhypertensive PRES that occurred in close temporal association with IVIG treatment and caused stroke. Immunoadsorption ameliorated the disease course. Our case supports the notion that in severe cases, immunoadsorption should be considered as first-line therapy instead of IVIG for rapid removal of IgG and thus to hasten recovery and improve functional outcome.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333) (POF2-333)
2. 89572 - (Dys-)function and Plasticity (POF2-89572) (POF2-89572)

Appears in the scientific report 2014

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Database coverage:
; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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