Journal Article

PreJuSER-17818

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Fast network oscillations in vitro exhibit a slow decay of temporal auto-correlations

Poil, S. S. ; Jansen, R. ; van Aerde, K.FZJ* ; Timmerman, J. ; Brussaard, A. B. ; Mansvelder, H. D. ; Linkenkaer-Hansen, K.

2011
Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/j.1460-9568.2011.07748.x

Abstract: Ongoing neuronal oscillations in vivo exhibit non-random amplitude fluctuations as reflected in a slow decay of temporal auto-correlations that persist for tens of seconds. Interestingly, the decay of auto-correlations is altered in several brain-related disorders, including epilepsy, depression and Alzheimer's disease, suggesting that the temporal structure of oscillations depends on intact neuronal networks in the brain. Whether structured amplitude modulation occurs only in the intact brain or whether isolated neuronal networks can also give rise to amplitude modulation with a slow decay is not known. Here, we examined the temporal structure of cholinergic fast network oscillations in acute hippocampal slices. For the first time, we show that a slow decay of temporal correlations can emerge from synchronized activity in isolated hippocampal networks from mice, and is maximal at intermediate concentrations of the cholinergic agonist carbachol. Using zolpidem, a positive allosteric modulator of GABA(A) receptor function, we found that increased inhibition leads to longer oscillation bursts and more persistent temporal correlations. In addition, we asked if these findings were unique for mouse hippocampus, and we therefore analysed cholinergic fast network oscillations in rat prefrontal cortex slices. We observed significant temporal correlations, which were similar in strength to those found in mouse hippocampus and human cortex. Taken together, our data indicate that fast network oscillations with temporal correlations can be induced in isolated networks in vitro in different species and brain areas, and therefore may serve as model systems to investigate how altered temporal correlations in disease may be rescued with pharmacology.

Keyword(s): Animals (MeSH) ; Carbachol: pharmacology (MeSH) ; Cholinergic Agonists: pharmacology (MeSH) ; Dose-Response Relationship, Drug (MeSH) ; Electrophysiology (MeSH) ; GABA-A Receptor Agonists: pharmacology (MeSH) ; Hippocampus: anatomy & histology (MeSH) ; Hippocampus: drug effects (MeSH) ; Hippocampus: physiology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Membrane Potentials: physiology (MeSH) ; Mice (MeSH) ; Mice, Inbred DBA (MeSH) ; Nerve Net: anatomy & histology (MeSH) ; Nerve Net: drug effects (MeSH) ; Nerve Net: physiology (MeSH) ; Periodicity (MeSH) ; Prefrontal Cortex: anatomy & histology (MeSH) ; Prefrontal Cortex: drug effects (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Pyridines: pharmacology (MeSH) ; Rats (MeSH) ; Rats, Wistar (MeSH) ; Cholinergic Agonists ; GABA-A Receptor Agonists ; Pyridines ; Carbachol ; zolpidem ; J ; acetylcholine (auto) ; memory (auto) ; mouse (auto) ; ongoing oscillations (auto) ; temporal auto-correlations (auto)

Note: This work was supported by The Netherlands Organization for Scientific Research (NWO) [Toptalent grant to S.-S.P.; R.J. was supported by a Computational Life Sciences grant (635.100.005); Innovative Research Incentive Schemes grant to K. L.-H.], the Neuro-Bsik Mouse Phenomics consortium (http://www.neurobsik.nl) (grant to A. B. B), the Royal Netherlands Academy of Arts and Sciences (KNAW) (fellowship to H. D. M.), and the Danish Research Agency (to K.L.-H.).

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)

Appears in the scientific report 2011

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