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000186053 0247_ $$2doi$$a10.1007/978-3-319-02970-2_18
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000186053 037__ $$aFZJ-2015-00154
000186053 082__ $$a610
000186053 1001_ $$0P:(DE-HGF)0$$aMusiani, Francesco$$b0
000186053 245__ $$aChemosensorial G-proteins-Coupled Receptors: A Perspective from Computational Methods
000186053 260__ $$aCham$$bSpringer International Publishing$$c2014
000186053 29510 $$aProtein Conformational Dynamics
000186053 300__ $$a441 - 457
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000186053 4900_ $$aAdvances in Experimental Medicine and Biology$$v805
000186053 520__ $$aG-protein coupled receptors (GPCRs) constitute the targets of about 40 % of all the pharmaceutical drugs in the market and, among other functions, a large portion of the family detects odorants and a variety of tastant molecules. Computational techniques are instrumental to understand structure, dynamics and function of the cascades triggered by these receptors. As an example, here we report our own computational work aimed to dissect GPCR molecular mechanisms for chemical senses. The implications of our work for systems biology and for pharmacology are discussed.
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000186053 7001_ $$0P:(DE-Juel1)145921$$aRossetti, Giulia$$b1
000186053 7001_ $$0P:(DE-HGF)0$$aGiorgetti, Alejandro$$b2$$eCorresponding Author
000186053 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b3
000186053 773__ $$a10.1007/978-3-319-02970-2_18$$y2014
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000186053 9141_ $$y2014
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