TY  - CHAP
AU  - Musiani, Francesco
AU  - Rossetti, Giulia
AU  - Giorgetti, Alejandro
AU  - Carloni, Paolo
TI  - Chemosensorial G-proteins-Coupled Receptors: A Perspective from Computational Methods
VL  - 805
CY  - Cham
PB  - Springer International Publishing
M1  - FZJ-2015-00154
SN  - 978-3-319-02969-6 (print)
T2  - Advances in Experimental Medicine and Biology
SP  - 441 - 457
PY  - 2014
AB  - G-protein coupled receptors (GPCRs) constitute the targets of about 40 % of all the pharmaceutical drugs in the market and, among other functions, a large portion of the family detects odorants and a variety of tastant molecules. Computational techniques are instrumental to understand structure, dynamics and function of the cascades triggered by these receptors. As an example, here we report our own computational work aimed to dissect GPCR molecular mechanisms for chemical senses. The implications of our work for systems biology and for pharmacology are discussed.
LB  - PUB:(DE-HGF)7
UR  - <Go to ISI:>//WOS:000350417100018
DO  - DOI:10.1007/978-3-319-02970-2_18
UR  - https://juser.fz-juelich.de/record/186053
ER  -