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000186384 037__ $$aFZJ-2015-00460
000186384 1001_ $$0P:(DE-Juel1)157910$$aJaksch, Sebastian$$b0$$eCorresponding Author$$ufzj
000186384 1112_ $$aDeutsche Tagung für Forschung mit Synchrotronstrahlung, Neutronen und Ionenstrahlen an Großgeräten 2014$$cBonn$$d2014-09-21 - 2014-09-23$$gSNI 2014$$wGermany
000186384 245__ $$aInfluence of Ibuprofen on Phospholipid Membranes
000186384 260__ $$c2014
000186384 3367_ $$033$$2EndNote$$aConference Paper
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000186384 3367_ $$2BibTeX$$aINPROCEEDINGS
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000186384 520__ $$aNonsteroidal anti-inflammatory drugs (NSAID) such as Ibuprofen have a wide range of medical applications, ranging from pain relieve to cancer [1] treatment. However, some applications require long-term application, which can lead to gastrointenstinal complications and even fatal ulcers [2]. Neutron reflectometry and grazing incidence neutron scattering (GISANS) investigations of lipid films, revealed a change in layer thickness upon the introduction of Ibuprofen. This change in layer thickness can be attributed to a different apparent hydration of the film [3].We investigated the influence of ibuprofen on phospholipid layers of L-α- phosphatidylcholine (SoyPC) between 0 and 33 wt% of ibuprofen. Our investigations have revealed that ibuprofen induces a two-step ordering in such films depending on the concentration. While there is no ordering for the pure SoyPC film, at higher concentrations ordering occurs. This ordering is a superposition of hexagonal and simple cubic lattices.There is a reorganisation at even higher concentrations of ibuprofen, leaving a single hexagonal structure.[1] Thun, M. J.; Henley, S. J.; Patrono, C. J. Natl. Cancer Inst. 2002, 94, 252−266.[2] Lichtenberger, L. M.; Barreto et al., J. C. Nat. Med. 1995, 1, 154−158.[3] S. Aeffner, T.; T. Salditt et al., Proc. Natl. Acad. Sci. USA, online, doi:10.1073/pnas.1119442109
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000186384 773__ $$y2014
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