Conference Presentation (After Call)

FZJ-2015-00460

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Influence of Ibuprofen on Phospholipid Membranes

Jaksch, S. (Corresponding Author)FZJ*

2014

Abstract: Nonsteroidal anti-inflammatory drugs (NSAID) such as Ibuprofen have a wide range of medical applications, ranging from pain relieve to cancer [1] treatment. However, some applications require long-term application, which can lead to gastrointenstinal complications and even fatal ulcers [2]. Neutron reflectometry and grazing incidence neutron scattering (GISANS) investigations of lipid films, revealed a change in layer thickness upon the introduction of Ibuprofen. This change in layer thickness can be attributed to a different apparent hydration of the film [3].We investigated the influence of ibuprofen on phospholipid layers of L-α- phosphatidylcholine (SoyPC) between 0 and 33 wt% of ibuprofen. Our investigations have revealed that ibuprofen induces a two-step ordering in such films depending on the concentration. While there is no ordering for the pure SoyPC film, at higher concentrations ordering occurs. This ordering is a superposition of hexagonal and simple cubic lattices.There is a reorganisation at even higher concentrations of ibuprofen, leaving a single hexagonal structure.[1] Thun, M. J.; Henley, S. J.; Patrono, C. J. Natl. Cancer Inst. 2002, 94, 252−266.[2] Lichtenberger, L. M.; Barreto et al., J. C. Nat. Med. 1995, 1, 154−158.[3] S. Aeffner, T.; T. Salditt et al., Proc. Natl. Acad. Sci. USA, online, doi:10.1073/pnas.1119442109

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Contributing Institute(s):

1. Neutronenstreuung (JCNS-1)

Research Program(s):

1. 54G - JCNS (POF2-54G24) (POF2-54G24)

Experiment(s):

1. MARIA: Magnetic reflectometer with high incident angle (NL5N)

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