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@INPROCEEDINGS{Jaksch:186384,
author = {Jaksch, Sebastian},
title = {{I}nfluence of {I}buprofen on {P}hospholipid {M}embranes},
reportid = {FZJ-2015-00460},
year = {2014},
abstract = {Nonsteroidal anti-inflammatory drugs (NSAID) such as
Ibuprofen have a wide range of medical applications, ranging
from pain relieve to cancer [1] treatment. However, some
applications require long-term application, which can lead
to gastrointenstinal complications and even fatal ulcers
[2]. Neutron reflectometry and grazing incidence neutron
scattering (GISANS) investigations of lipid films, revealed
a change in layer thickness upon the introduction of
Ibuprofen. This change in layer thickness can be attributed
to a different apparent hydration of the film [3].We
investigated the influence of ibuprofen on phospholipid
layers of L-α- phosphatidylcholine (SoyPC) between 0 and 33
$wt\%$ of ibuprofen. Our investigations have revealed that
ibuprofen induces a two-step ordering in such films
depending on the concentration. While there is no ordering
for the pure SoyPC film, at higher concentrations ordering
occurs. This ordering is a superposition of hexagonal and
simple cubic lattices.There is a reorganisation at even
higher concentrations of ibuprofen, leaving a single
hexagonal structure.[1] Thun, M. J.; Henley, S. J.; Patrono,
C. J. Natl. Cancer Inst. 2002, 94, 252−266.[2]
Lichtenberger, L. M.; Barreto et al., J. C. Nat. Med. 1995,
1, 154−158.[3] S. Aeffner, T.; T. Salditt et al., Proc.
Natl. Acad. Sci. USA, online, doi:10.1073/pnas.1119442109},
month = {Sep},
date = {2014-09-21},
organization = {Deutsche Tagung für Forschung mit
Synchrotronstrahlung, Neutronen und
Ionenstrahlen an Großgeräten 2014,
Bonn (Germany), 21 Sep 2014 - 23 Sep
2014},
subtyp = {After Call},
cin = {JCNS-1},
cid = {I:(DE-Juel1)JCNS-1-20110106},
pnm = {54G - JCNS (POF2-54G24)},
pid = {G:(DE-HGF)POF2-54G24},
experiment = {EXP:(DE-MLZ)MARIA-20140101},
typ = {PUB:(DE-HGF)6},
url = {https://juser.fz-juelich.de/record/186384},
}