% IMPORTANT: The following is UTF-8 encoded. This means that in the presence % of non-ASCII characters, it will not work with BibTeX 0.99 or older. % Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or % “biber”. @INPROCEEDINGS{Jaksch:186384, author = {Jaksch, Sebastian}, title = {{I}nfluence of {I}buprofen on {P}hospholipid {M}embranes}, reportid = {FZJ-2015-00460}, year = {2014}, abstract = {Nonsteroidal anti-inflammatory drugs (NSAID) such as Ibuprofen have a wide range of medical applications, ranging from pain relieve to cancer [1] treatment. However, some applications require long-term application, which can lead to gastrointenstinal complications and even fatal ulcers [2]. Neutron reflectometry and grazing incidence neutron scattering (GISANS) investigations of lipid films, revealed a change in layer thickness upon the introduction of Ibuprofen. This change in layer thickness can be attributed to a different apparent hydration of the film [3].We investigated the influence of ibuprofen on phospholipid layers of L-α- phosphatidylcholine (SoyPC) between 0 and 33 $wt\%$ of ibuprofen. Our investigations have revealed that ibuprofen induces a two-step ordering in such films depending on the concentration. While there is no ordering for the pure SoyPC film, at higher concentrations ordering occurs. This ordering is a superposition of hexagonal and simple cubic lattices.There is a reorganisation at even higher concentrations of ibuprofen, leaving a single hexagonal structure.[1] Thun, M. J.; Henley, S. J.; Patrono, C. J. Natl. Cancer Inst. 2002, 94, 252−266.[2] Lichtenberger, L. M.; Barreto et al., J. C. Nat. Med. 1995, 1, 154−158.[3] S. Aeffner, T.; T. Salditt et al., Proc. Natl. Acad. Sci. USA, online, doi:10.1073/pnas.1119442109}, month = {Sep}, date = {2014-09-21}, organization = {Deutsche Tagung für Forschung mit Synchrotronstrahlung, Neutronen und Ionenstrahlen an Großgeräten 2014, Bonn (Germany), 21 Sep 2014 - 23 Sep 2014}, subtyp = {After Call}, cin = {JCNS-1}, cid = {I:(DE-Juel1)JCNS-1-20110106}, pnm = {54G - JCNS (POF2-54G24)}, pid = {G:(DE-HGF)POF2-54G24}, experiment = {EXP:(DE-MLZ)MARIA-20140101}, typ = {PUB:(DE-HGF)6}, url = {https://juser.fz-juelich.de/record/186384}, }