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| Hauptseite > Publikationsdatenbank > Influence of Ibuprofen on Phospholipid Membranes > print |
| 001 | 186384 | ||
| 005 | 20240320203801.0 | ||
| 037 | _ | _ | |a FZJ-2015-00460 |
| 100 | 1 | _ | |a Jaksch, Sebastian |0 P:(DE-Juel1)157910 |b 0 |e Corresponding Author |u fzj |
| 111 | 2 | _ | |a Deutsche Tagung für Forschung mit Synchrotronstrahlung, Neutronen und Ionenstrahlen an Großgeräten 2014 |g SNI 2014 |c Bonn |d 2014-09-21 - 2014-09-23 |w Germany |
| 245 | _ | _ | |a Influence of Ibuprofen on Phospholipid Membranes |
| 260 | _ | _ | |c 2014 |
| 336 | 7 | _ | |a Conference Paper |0 33 |2 EndNote |
| 336 | 7 | _ | |a Other |2 DataCite |
| 336 | 7 | _ | |a INPROCEEDINGS |2 BibTeX |
| 336 | 7 | _ | |a conferenceObject |2 DRIVER |
| 336 | 7 | _ | |a LECTURE_SPEECH |2 ORCID |
| 336 | 7 | _ | |a Conference Presentation |b conf |m conf |0 PUB:(DE-HGF)6 |s 1710928166_27862 |2 PUB:(DE-HGF) |x After Call |
| 520 | _ | _ | |a Nonsteroidal anti-inflammatory drugs (NSAID) such as Ibuprofen have a wide range of medical applications, ranging from pain relieve to cancer [1] treatment. However, some applications require long-term application, which can lead to gastrointenstinal complications and even fatal ulcers [2]. Neutron reflectometry and grazing incidence neutron scattering (GISANS) investigations of lipid films, revealed a change in layer thickness upon the introduction of Ibuprofen. This change in layer thickness can be attributed to a different apparent hydration of the film [3].We investigated the influence of ibuprofen on phospholipid layers of L-α- phosphatidylcholine (SoyPC) between 0 and 33 wt% of ibuprofen. Our investigations have revealed that ibuprofen induces a two-step ordering in such films depending on the concentration. While there is no ordering for the pure SoyPC film, at higher concentrations ordering occurs. This ordering is a superposition of hexagonal and simple cubic lattices.There is a reorganisation at even higher concentrations of ibuprofen, leaving a single hexagonal structure.[1] Thun, M. J.; Henley, S. J.; Patrono, C. J. Natl. Cancer Inst. 2002, 94, 252−266.[2] Lichtenberger, L. M.; Barreto et al., J. C. Nat. Med. 1995, 1, 154−158.[3] S. Aeffner, T.; T. Salditt et al., Proc. Natl. Acad. Sci. USA, online, doi:10.1073/pnas.1119442109 |
| 536 | _ | _ | |a 54G - JCNS (POF2-54G24) |0 G:(DE-HGF)POF2-54G24 |c POF2-54G24 |f POF II |x 0 |
| 693 | _ | _ | |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz |e MARIA: Magnetic reflectometer with high incident angle |f NL5N |1 EXP:(DE-MLZ)FRMII-20140101 |0 EXP:(DE-MLZ)MARIA-20140101 |5 EXP:(DE-MLZ)MARIA-20140101 |6 EXP:(DE-MLZ)NL5N-20140101 |x 0 |
| 773 | _ | _ | |y 2014 |
| 909 | C | O | |o oai:juser.fz-juelich.de:186384 |p VDB |
| 910 | 1 | _ | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)157910 |
| 913 | 2 | _ | |a DE-HGF |b Forschungsbereich Materie |l Von Materie zu Materialien und Leben |1 G:(DE-HGF)POF3-620 |0 G:(DE-HGF)POF3-623 |2 G:(DE-HGF)POF3-600 |v Facility topic: Neutrons for Research on Condensed Matter |9 G:(DE-HGF)POF3-6G4 |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Struktur der Materie |l Forschung mit Photonen, Neutronen, Ionen |1 G:(DE-HGF)POF2-540 |0 G:(DE-HGF)POF2-54G24 |3 G:(DE-HGF)POF2 |2 G:(DE-HGF)POF2-500 |4 G:(DE-HGF)POF |v JCNS |x 0 |
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| 980 | _ | _ | |a conf |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-1-20110106 |
| 980 | _ | _ | |a UNRESTRICTED |
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