Gast ::
| Hauptseite > Publikationsdatenbank > Hierarchical molecular dynamics of bovine serum albumin in concentrated aqueous solution below and above thermal denaturation > print |
| Hauptseite > Publikationsdatenbank > Hierarchical molecular dynamics of bovine serum albumin in concentrated aqueous solution below and above thermal denaturation > print |
| 001 | 187418 | ||
| 005 | 20240619092100.0 | ||
| 024 | 7 | _ | |a 10.1039/C4CP04944F |2 doi |
| 024 | 7 | _ | |a 1463-9076 |2 ISSN |
| 024 | 7 | _ | |a 1463-9084 |2 ISSN |
| 024 | 7 | _ | |a 2128/8329 |2 Handle |
| 024 | 7 | _ | |a WOS:000349005900077 |2 WOS |
| 024 | 7 | _ | |a altmetric:21825002 |2 altmetric |
| 024 | 7 | _ | |a pmid:25587698 |2 pmid |
| 037 | _ | _ | |a FZJ-2015-01087 |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Grimaldo, Marco |b 0 |e Corresponding Author |
| 245 | _ | _ | |a Hierarchical molecular dynamics of bovine serum albumin in concentrated aqueous solution below and above thermal denaturation |
| 260 | _ | _ | |a Cambridge |b RSC Publ. |c 2015 |
| 336 | 7 | _ | |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |a Journal Article |b journal |m journal |s 1429681061_3348 |
| 336 | 7 | _ | |2 DataCite |a Output Types/Journal article |
| 336 | 7 | _ | |0 0 |2 EndNote |a Journal Article |
| 336 | 7 | _ | |2 BibTeX |a ARTICLE |
| 336 | 7 | _ | |2 ORCID |a JOURNAL_ARTICLE |
| 336 | 7 | _ | |2 DRIVER |a article |
| 520 | _ | _ | |a The dynamics of proteins in solution is a complex and hierarchical process, affected by the aqueous environment as well as temperature. We present a comprehensive study on nanosecond time and nanometer length scales below, at, and above the denaturation temperature Td. Our experimental data evidence dynamical processes in protein solutions on three distinct time scales. We suggest a consistent physical picture of hierarchical protein dynamics: (i) self-diffusion of the entire protein molecule is confirmed to agree with colloid theory for all temperatures where the protein is in its native conformational state. At higher temperatures T > Td, the self-diffusion is strongly obstructed by cross-linking or entanglement. (ii) The amplitude of backbone fluctuations grows with increasing T, and a transition in its dynamics is observed above Td. (iii) The number of mobile side-chains increases sharply at Td while their average dynamics exhibits only little variations. The combination of quasi-elastic neutron scattering and the presented analytical framework provides a detailed microscopic picture of the protein molecular dynamics in solution, thereby reflecting the changes of macroscopic properties such as cluster formation and gelation. |
| 536 | _ | _ | |0 G:(DE-HGF)POF3-551 |a 551 - Functional Macromolecules and Complexes (POF3-551) |c POF3-551 |f POF III |x 0 |
| 536 | _ | _ | |0 G:(DE-HGF)POF3-6G4 |a 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) |c POF3-623 |f POF III |x 1 |
| 536 | _ | _ | |0 G:(DE-HGF)POF3-6215 |a 6215 - Soft Matter, Health and Life Sciences (POF3-621) |c POF3-621 |f POF III |x 2 |
| 588 | _ | _ | |a Dataset connected to CrossRef, juser.fz-juelich.de |
| 650 | 2 | 7 | |0 V:(DE-MLZ)SciArea-210 |2 V:(DE-HGF) |a Soft Condensed Matter |x 0 |
| 650 | 1 | 7 | |a Health and Life |0 V:(DE-MLZ)GC-130-2016 |2 V:(DE-HGF) |x 1 |
| 650 | 1 | 7 | |a Health and Life |0 V:(DE-MLZ)GC-130-1 |2 V:(DE-HGF) |x 0 |
| 693 | _ | _ | |0 EXP:(DE-MLZ)External-20140101 |5 EXP:(DE-MLZ)External-20140101 |e Measurement at external facility |x 0 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Roosen-Runge, Felix |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Hennig, Marcus |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Zanini, Fabio |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Zhang, Fajun |b 4 |
| 700 | 1 | _ | |0 P:(DE-Juel1)143752 |a Jalarvo, Niina |b 5 |u fzj |
| 700 | 1 | _ | |0 P:(DE-Juel1)131056 |a Zamponi, Michaela |b 6 |u fzj |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Schreiber, Frank |b 7 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Seydel, Tilo |b 8 |
| 773 | _ | _ | |0 PERI:(DE-600)1476244-4 |a 10.1039/C4CP04944F |g Vol. 17, no. 6, p. 4645 - 4655 |n 6 |p 4645 - 4655 |t Physical chemistry, chemical physics |v 17 |x 1463-9084 |y 2015 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/187418/files/FZJ-2015-01087.pdf |y OpenAccess |
| 909 | C | O | |o oai:juser.fz-juelich.de:187418 |p openaire |p VDB:MLZ |p driver |p open_access |p VDB |p dnbdelivery |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)143752 |a Forschungszentrum Jülich GmbH |b 5 |k FZJ |
| 910 | 1 | _ | |0 I:(DE-588b)5008462-8 |6 P:(DE-Juel1)131056 |a Forschungszentrum Jülich GmbH |b 6 |k FZJ |
| 913 | 0 | _ | |0 G:(DE-HGF)POF2-451 |1 G:(DE-HGF)POF2-450 |2 G:(DE-HGF)POF2-400 |a DE-HGF |b Schlüsseltechnologien |l BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |v Soft Matter Composites |x 0 |
| 913 | 0 | _ | |0 G:(DE-HGF)POF2-54G24 |1 G:(DE-HGF)POF2-540 |2 G:(DE-HGF)POF2-500 |a DE-HGF |b Struktur der Materie |l Forschung mit Photonen, Neutronen und Ionen (PNI) |v JCNS |x 1 |
| 913 | 1 | _ | |0 G:(DE-HGF)POF3-551 |1 G:(DE-HGF)POF3-550 |2 G:(DE-HGF)POF3-500 |a DE-HGF |b Key Technologies |l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences |v Functional Macromolecules and Complexes |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 913 | 1 | _ | |0 G:(DE-HGF)POF3-623 |1 G:(DE-HGF)POF3-620 |2 G:(DE-HGF)POF3-600 |9 G:(DE-HGF)POF3-6G4 |a DE-HGF |b Forschungsbereich Materie |l Von Materie zu Materialien und Leben |v Facility topic: Neutrons for Research on Condensed Matter |x 1 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 913 | 1 | _ | |0 G:(DE-HGF)POF3-621 |1 G:(DE-HGF)POF3-620 |2 G:(DE-HGF)POF3-600 |9 G:(DE-HGF)POF3-6215 |a DE-HGF |b Forschungsbereich Materie |l Von Materie zu Materialien und Leben |v In-house research on the structure, dynamics and function of matter |x 2 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2015 |
| 915 | _ | _ | |0 LIC:(DE-HGF)CCBYNC3 |2 HGFVOC |a Creative Commons Attribution-NonCommercial CC BY-NC 3.0 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0100 |2 StatID |a JCR |
| 915 | _ | _ | |0 StatID:(DE-HGF)0110 |2 StatID |a WoS |b Science Citation Index |
| 915 | _ | _ | |0 StatID:(DE-HGF)0111 |2 StatID |a WoS |b Science Citation Index Expanded |
| 915 | _ | _ | |0 StatID:(DE-HGF)0150 |2 StatID |a DBCoverage |b Web of Science Core Collection |
| 915 | _ | _ | |0 StatID:(DE-HGF)0199 |2 StatID |a DBCoverage |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |0 StatID:(DE-HGF)0200 |2 StatID |a DBCoverage |b SCOPUS |
| 915 | _ | _ | |0 StatID:(DE-HGF)0300 |2 StatID |a DBCoverage |b Medline |
| 915 | _ | _ | |0 StatID:(DE-HGF)0310 |2 StatID |a DBCoverage |b NCBI Molecular Biology Database |
| 915 | _ | _ | |0 StatID:(DE-HGF)0400 |2 StatID |a Allianz-Lizenz / DFG |
| 915 | _ | _ | |0 StatID:(DE-HGF)0420 |2 StatID |a Nationallizenz |
| 915 | _ | _ | |0 StatID:(DE-HGF)0510 |2 StatID |a OpenAccess |
| 915 | _ | _ | |0 StatID:(DE-HGF)1150 |2 StatID |a DBCoverage |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |0 StatID:(DE-HGF)9900 |2 StatID |a IF < 5 |
| 920 | 1 | _ | |0 I:(DE-Juel1)ICS-1-20110106 |k ICS-1 |l Neutronenstreuung |x 0 |
| 920 | 1 | _ | |0 I:(DE-Juel1)JCNS-1-20110106 |k Neutronenstreuung ; JCNS-1 |l Neutronenstreuung |x 1 |
| 920 | 1 | _ | |0 I:(DE-Juel1)JCNS-SNS-20110128 |k Jülich Centre for Neutron Science JCNS (JCNS) ; JCNS |l JCNS-SNS |x 2 |
| 920 | 1 | _ | |0 I:(DE-Juel1)JCNS-FRM-II-20110218 |k JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II |l JCNS-FRM-II |x 3 |
| 980 | 1 | _ | |a FullTexts |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-1-20110106 |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-1-20110106 |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-SNS-20110128 |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-FRM-II-20110218 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a FullTexts |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-8-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-1-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-1-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-SNS-20110128 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-FRM-II-20110218 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|