TY  - JOUR
AU  - Jaksch, Sebastian
AU  - Lipfert, Frederik
AU  - Koutsioumpas, Alexandros
AU  - Mattauch, Stefan
AU  - Holderer, Olaf
AU  - Ivanova, Oxana
AU  - Frielinghaus, Henrich
AU  - Hertrich, Samira
AU  - Fischer, Stefan F.
AU  - Nickel, Bert
TI  - Influence of ibuprofen on phospholipid membranes
JO  - Physical review / E
VL  - 91
IS  - 2
SN  - 1539-3755
CY  - College Park, Md.
PB  - APS
M1  - FZJ-2015-01661
SP  - 022716
PY  - 2015
AB  - A basic understanding of biological membranes is of paramount importance as these membranes comprise the very building blocks of life itself. Cells depend in their function on a range of properties of the membrane, which are important for the stability and function of the cell, information and nutrient transport, waste disposal, and finally the admission of drugs into the cell and also the deflection of bacteria and viruses. We have investigated the influence of ibuprofen on the structure and dynamics of L-α-phosphatidylcholine (SoyPC) membranes by means of grazing incidence small-angle neutron scattering, neutron reflectometry, and grazing incidence neutron spin echo spectroscopy. From the results of these experiments, we were able to determine that ibuprofen induces a two-step structuring behavior in the SoyPC films, where the structure evolves from the purely lamellar phase for pure SoyPC over a superposition of two hexagonal phases to a purely hexagonal phase at high concentrations. A relaxation, which is visible when no ibuprofen is present in the membrane, vanishes upon addition of ibuprofen. This we attribute to a stiffening of the membrane. This behavior may be instrumental in explaining the toxic behavior of ibuprofen in long-term application.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000350107200006
DO  - DOI:10.1103/PhysRevE.91.022716
UR  - https://juser.fz-juelich.de/record/188219
ER  -