Journal Article

FZJ-2015-01661

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Influence of ibuprofen on phospholipid membranes

Jaksch, S. (Corresponding Author)FZJ* ; Lipfert, F.FZJ* ; Koutsioumpas, A.FZJ* ; Mattauch, S.FZJ* ; Holderer, O.FZJ* ; Ivanova, O.FZJ* ; Frielinghaus, H.FZJ* ; Hertrich, S. ; Fischer, S. F. ; Nickel, B.

2015
APS College Park, Md.

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Please use a persistent id in citations: http://hdl.handle.net/2128/9220  doi:10.1103/PhysRevE.91.022716

Abstract: A basic understanding of biological membranes is of paramount importance as these membranes comprise the very building blocks of life itself. Cells depend in their function on a range of properties of the membrane, which are important for the stability and function of the cell, information and nutrient transport, waste disposal, and finally the admission of drugs into the cell and also the deflection of bacteria and viruses. We have investigated the influence of ibuprofen on the structure and dynamics of L-α-phosphatidylcholine (SoyPC) membranes by means of grazing incidence small-angle neutron scattering, neutron reflectometry, and grazing incidence neutron spin echo spectroscopy. From the results of these experiments, we were able to determine that ibuprofen induces a two-step structuring behavior in the SoyPC films, where the structure evolves from the purely lamellar phase for pure SoyPC over a superposition of two hexagonal phases to a purely hexagonal phase at high concentrations. A relaxation, which is visible when no ibuprofen is present in the membrane, vanishes upon addition of ibuprofen. This we attribute to a stiffening of the membrane. This behavior may be instrumental in explaining the toxic behavior of ibuprofen in long-term application.

Keyword(s): Health and Life (1st) ; Health and Life (1st) ; Soft Matter, Macromolecules, Complex fluids, Biophysics (1st) ; Biology (2nd) ; Soft Condensed Matter (2nd) ; Medicine (2nd)

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Contributing Institute(s):

1. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
2. Neutronenstreuung (Neutronenstreuung ; JCNS-1)
3. Neutronenstreuung (ICS-1)
4. Streumethoden (JCNS-2)
5. Streumethoden (PGI-4)
6. JARA-FIT (JARA-FIT)

Research Program(s):

1. 144 - Controlling Collective States (POF3-144) (POF3-144)
2. 524 - Controlling Collective States (POF3-524) (POF3-524)
3. 6215 - Soft Matter, Health and Life Sciences (POF3-621) (POF3-621)
4. 6G15 - FRM II / MLZ (POF3-6G15) (POF3-6G15)
5. 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) (POF3-623)

Experiment(s):

1. J-NSE: Neutron spin-echo spectrometer (NL2ao)
2. MARIA: Magnetic reflectometer with high incident angle (NL5N)

Appears in the scientific report 2015

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Database coverage:
; ; ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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