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@ARTICLE{Jaksch:188219,
      author       = {Jaksch, Sebastian and Lipfert, Frederik and Koutsioumpas,
                      Alexandros and Mattauch, Stefan and Holderer, Olaf and
                      Ivanova, Oxana and Frielinghaus, Henrich and Hertrich,
                      Samira and Fischer, Stefan F. and Nickel, Bert},
      title        = {{I}nfluence of ibuprofen on phospholipid membranes},
      journal      = {Physical review / E},
      volume       = {91},
      number       = {2},
      issn         = {1539-3755},
      address      = {College Park, Md.},
      publisher    = {APS},
      reportid     = {FZJ-2015-01661},
      pages        = {022716},
      year         = {2015},
      abstract     = {A basic understanding of biological membranes is of
                      paramount importance as these membranes comprise the very
                      building blocks of life itself. Cells depend in their
                      function on a range of properties of the membrane, which are
                      important for the stability and function of the cell,
                      information and nutrient transport, waste disposal, and
                      finally the admission of drugs into the cell and also the
                      deflection of bacteria and viruses. We have investigated the
                      influence of ibuprofen on the structure and dynamics of
                      L-α-phosphatidylcholine (SoyPC) membranes by means of
                      grazing incidence small-angle neutron scattering, neutron
                      reflectometry, and grazing incidence neutron spin echo
                      spectroscopy. From the results of these experiments, we were
                      able to determine that ibuprofen induces a two-step
                      structuring behavior in the SoyPC films, where the structure
                      evolves from the purely lamellar phase for pure SoyPC over a
                      superposition of two hexagonal phases to a purely hexagonal
                      phase at high concentrations. A relaxation, which is visible
                      when no ibuprofen is present in the membrane, vanishes upon
                      addition of ibuprofen. This we attribute to a stiffening of
                      the membrane. This behavior may be instrumental in
                      explaining the toxic behavior of ibuprofen in long-term
                      application.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      ICS-1 / JCNS-2 / PGI-4 / JARA-FIT},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)ICS-1-20110106 /
                      I:(DE-Juel1)JCNS-2-20110106 / I:(DE-Juel1)PGI-4-20110106 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {144 - Controlling Collective States (POF3-144) / 524 -
                      Controlling Collective States (POF3-524) / 6215 - Soft
                      Matter, Health and Life Sciences (POF3-621) / 6G15 - FRM II
                      / MLZ (POF3-6G15) / 6G4 - Jülich Centre for Neutron
                      Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-144 / G:(DE-HGF)POF3-524 /
                      G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G15 /
                      G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)J-NSE-20140101 / EXP:(DE-MLZ)MARIA-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000350107200006},
      doi          = {10.1103/PhysRevE.91.022716},
      url          = {https://juser.fz-juelich.de/record/188219},
}