Journal Article

FZJ-2015-01750

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A roadmap for interpreting 13C metabolite labeling patterns from cells

Buescher, J. M. (Corresponding Author) ; Antoniewicz, M. R. ; Boros, L. G. ; Burgess, S. C. ; Brunengraber, H. ; Clish, C. B. ; DeBerardinis, R. J. ; Feron, O. ; Frezza, C. ; Ghesquiere, B. ; Gottlieb, E. ; Hiller, K. ; Jones, R. G. ; Kamphorst, J. J. ; Kibbey, R. G. ; Kimmelman, A. C. ; Locasale, J. W. ; Lunt, S. Y. ; Maddocks, O. D. ; Malloy, C. ; Metallo, C. M. ; Meuillet, E. J. ; Munger, J. ; Nöh, K.FZJ* ; Rabinowitz, J. D. ; Ralser, M. ; Sauer, U. ; Stephanopoulos, G. ; St-Pierre, J. ; Tennant, D. A. ; Wittmann, C. ; Vander Heiden, M. G. ; Vazquez, A. ; Vousden, K. ; Young, J. D. ; Zamboni, N. ; Fendt, S.-M.

2015
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.copbio.2015.02.003

Abstract: Measuring intracellular metabolism has increasingly led to important insights in biomedical research. 13C tracer analysis, although less information-rich than quantitative 13C flux analysis that requires computational data integration, has been established as a time-efficient method to unravel relative pathway activities, qualitative changes in pathway contributions, and nutrient contributions. Here, we review selected key issues in interpreting 13C metabolite labeling patterns, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.

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Contributing Institute(s):

1. Biotechnologie (IBG-1)

Research Program(s):

1. 581 - Biotechnology (POF3-581) (POF3-581)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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