Journal Article

FZJ-2015-01954

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

Kuhn, J. (Corresponding Author) ; Hardenacke, K. ; Lenartz, D. ; Gruendler, T. ; Ullsperger, M. ; Bartsch, C. ; Mai, J. K. ; Zilles, K.FZJ* ; Bauer, A.FZJ* ; Matusch, A.FZJ* ; Schulz, R.-J. ; Noreik, M. ; Bührle, C. P. ; Maintz, D. ; Woopen, C. ; Häussermann, P. ; Hellmich, M. ; Klosterkötter, J. ; Wiltfang, J. ; Maarouf, M. ; Freund, H.-J.FZJ* ; Sturm, V.

2015
Macmillan London

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Please use a persistent id in citations: doi:10.1038/mp.2014.32

Abstract: Cholinergic neurons of the medial forebrain are considered important contributors to brain plasticity and neuromodulation. A reduction of cholinergic innervation can lead to pathophysiological changes of neurotransmission and is observed in Alzheimer’s disease. Here we report on six patients with mild to moderate Alzheimer’s disease (AD) treated with bilateral low-frequency deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM). During a four-week double-blind sham-controlled phase and a subsequent 11-month follow-up open label period, clinical outcome was assessed by neuropsychological examination using the Alzheimer’s Disease Assessment Scale—cognitive subscale as the primary outcome measure. Electroencephalography and [18F]-fluoro-desoxyglucose positron emission tomography were, besides others, secondary endpoints. On the basis of stable or improved primary outcome parameters twelve months after surgery, four of the six patients were considered responders. No severe or non-transitional side effects related to the stimulation were observed. Taking into account all limitations of a pilot study, we conclude that DBS of the NBM is both technically feasible and well tolerated.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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