Journal Article

FZJ-2015-02192

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sex Differences in Cognitive Training Effects of Patients with Amnestic Mild Cognitive Impairment.

Rahe, J. ; Liesk, J. ; Rosen, J. ; Petrelli, A. ; Kaesberg, S.FZJ* ; Özgür, O.FZJ* ; Kessler, J. ; Fink, G. R.FZJ* ; Kalbe, E.

2015
Swets & Zeitlinger Lisse

This record in other databases:      

Please use a persistent id in citations: doi:10.1080/13825585.2015.1028883

Abstract: Cognitive training has been shown to be effective in improving cognitive functions in patients with Mild Cognitive Impairment (MCI). However, data on factors that may influence training gains including sociodemographic variables such as sex or age is rare. In this study, the impact of sex on cognitive training effects was examined in N = 32 age- and education-matched female (n = 16) and male (n = 16) amnestic MCI patients (total sample: age M = 74.97, SD = 5.21; education M = 13.50, SD = 3.11). Patients participated in a six-week multidomain cognitive training program including 12 sessions each 90 min twice weekly in mixed groups with both women and men. Various cognitive domains were assessed before and after the intervention. Despite comparable baseline performance in women and men, we found significant interaction effects Time × Sex in immediate (p = .04) and delayed verbal episodic memory (p= .045) as well as in working memory (p = .042) favoring the female MCI patients. In contrast, the overall analyses with the total sample did not reveal any significant within-subject effects Time. In conclusion, our results give preliminary evidence for stronger cognitive training improvements of female compared to male MCI patients. More generally, they emphasize the importance of sex-sensitive evaluations of cognitive training effects. Possible underlying mechanisms of the found sex differences are discussed and directions for future research are given.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2015

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Database coverage:
; Current Contents - Social and Behavioral Sciences ; IF < 5 ; JCR ; SCOPUS ; Social Sciences Citation Index ; Thomson Reuters Master Journal List

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