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@ARTICLE{Podewitz:189573,
      author       = {Podewitz, Nils and Delarue, M. and Elgeti, Jens},
      title        = {{T}issue homeostasis: {A} tensile state},
      journal      = {epl},
      volume       = {109},
      number       = {5},
      issn         = {1286-4854},
      address      = {Les Ulis},
      publisher    = {EDP Sciences},
      reportid     = {FZJ-2015-02713},
      pages        = {58005},
      year         = {2015},
      abstract     = {Mechanics play a significant role during tissue
                      development. One of the key characteristics that underlies
                      this mechanical role is the homeostatic pressure, which is
                      the pressure stalling growth. In this work, we explore the
                      possibility of a negative bulk homeostatic pressure by means
                      of a mesoscale simulation approach and experimental data of
                      several cell lines. We show how different cell properties
                      change the bulk homeostatic pressure, which could explain
                      the benefit of some observed morphological changes during
                      cancer progression. Furthermore, we study the dependence of
                      growth on pressure and estimate the bulk homeostatic
                      pressure of five cell lines. Four out of five result in a
                      bulk homeostatic pressure in the order of minus one or two
                      kPa.},
      cin          = {IAS-2 / ICS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000352397500026},
      doi          = {10.1209/0295-5075/109/58005},
      url          = {https://juser.fz-juelich.de/record/189573},
}