Journal Article

FZJ-2015-02713

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tissue homeostasis: A tensile state

Podewitz, N. (Corresponding Author)FZJ* ; Delarue, M. ; Elgeti, J.FZJ*

2015
EDP Sciences Les Ulis

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Please use a persistent id in citations: http://hdl.handle.net/2128/19748  doi:10.1209/0295-5075/109/58005

Abstract: Mechanics play a significant role during tissue development. One of the key characteristics that underlies this mechanical role is the homeostatic pressure, which is the pressure stalling growth. In this work, we explore the possibility of a negative bulk homeostatic pressure by means of a mesoscale simulation approach and experimental data of several cell lines. We show how different cell properties change the bulk homeostatic pressure, which could explain the benefit of some observed morphological changes during cancer progression. Furthermore, we study the dependence of growth on pressure and estimate the bulk homeostatic pressure of five cell lines. Four out of five result in a bulk homeostatic pressure in the order of minus one or two kPa.

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (IAS-2)
2. Theorie der Weichen Materie und Biophysik (ICS-2)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)

Appears in the scientific report 2015

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Database coverage:
; ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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