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@ARTICLE{Abbas:189738,
      author       = {Abbas, Zaheer and Gras, Vincent and Möllenhoff, Klaus and
                      Oros-Peusquens, Ana-Maria and Shah, Nadim Joni},
      title        = {{Q}uantitative water content mapping at clinically relevant
                      field strengths: {A} comparative study at 1.5{T} and 3{T}},
      journal      = {NeuroImage},
      volume       = {106},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2015-02770},
      pages        = {404 - 413},
      year         = {2015},
      abstract     = {PurposeQuantitative water content mapping in vivo using MRI
                      is a very valuable technique to detect, monitor and
                      understand diseases of the brain. At 1.5 T, this technology
                      has already been successfully used, but it has only recently
                      been applied at 3 T because of significantly increased RF
                      field inhomogeneity at the higher field strength. To
                      validate the technology at 3 T, we estimate and compare in
                      vivo quantitative water content maps at 1.5 T and 3 T
                      obtained with a protocol proposed recently for 3 T
                      MRI.MethodsThe proposed MRI protocol was applied on twenty
                      healthy subjects at 1.5 T and 3 T; the same post-processing
                      algorithms were used to estimate the water content maps. The
                      1.5 T and 3 T maps were subsequently aligned and compared on
                      a voxel-by-voxel basis. Statistical analysis was performed
                      to detect possible differences between the estimated 1.5 T
                      and 3 T water maps.ResultsOur analysis indicates that the
                      water content values obtained at 1.5 T and 3 T did not show
                      significant systematic differences. On average the
                      difference did not exceed the standard deviation of the
                      water content at 1.5 T. Furthermore, the contrast-to-noise
                      ratio (CNR) of the estimated water content map was increased
                      at 3 T by a factor of at least 1.5.ConclusionsVulnerability
                      to RF inhomogeneity increases dramatically with the
                      increasing static magnetic field strength. However, using
                      advanced corrections for the sensitivity profile of the MR
                      coils, it is possible to preserve quantitative accuracy
                      while benefiting from the increased CNR at the higher field
                      strength. Indeed, there was no significant difference in the
                      water content values obtained in the brain at 1.5 T and 3
                      T.},
      cin          = {INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000347101900037},
      doi          = {10.1016/j.neuroimage.2014.11.017},
      url          = {https://juser.fz-juelich.de/record/189738},
}