Journal Article

FZJ-2015-03321

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Bioimaging mass spectrometry of trace elements – recent advance and applications of LA-ICP-MS: A review

Becker, J. S.FZJ* ; Matusch, A. (Corresponding Author)FZJ* ; Wu, B.FZJ*

2014
Elsevier Science Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.aca.2014.04.048

Abstract: Bioimaging using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) offers the capability to quantify trace elements and isotopes within tissue sections with a spatial resolution ranging about 10–100 μm. Distribution analysis adds to clarifying basic questions of biomedical research and enables bioaccumulation and bioavailability studies for ecological and toxicological risk assessment in humans, animals and plants. Major application fields of mass spectrometry imaging (MSI) and metallomics have been in brain and cancer research, animal model validation, drug development and plant science. Here we give an overview of latest achievements in methods and applications. Recent improvements in ablation systems, operation and cell design enabled progressively better spatial resolutions down to 1 μm. Meanwhile, a body of research has accumulated covering basic principles of the element architecture in animals and plants that could consistently be reproduced by several laboratories such as the distribution of Fe, Cu, Zn in rodent brain. Several studies investigated the distribution and delivery of metallo-drugs in animals. Hyper-accumulating plants and pollution indicator organisms have been the key topics in environmental science. Increasingly, larger series of samples are analyzed, may it be in the frame of comparisons between intervention and control groups, of time kinetics or of three-dimensional atlas approaches.

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Contributing Institute(s):

1. Analytik (ZEA-3)
2. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF2-313) (POF2-313)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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