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@ARTICLE{Becker:201007,
      author       = {Becker, J. Sabine and Matusch, Andreas and Wu, Bei},
      title        = {{B}ioimaging mass spectrometry of trace elements – recent
                      advance and applications of {LA}-{ICP}-{MS}: {A} review},
      journal      = {Analytica chimica acta},
      volume       = {835},
      issn         = {0003-2670},
      address      = {Amsterdam},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2015-03321},
      pages        = {1 - 18},
      year         = {2014},
      abstract     = {Bioimaging using laser ablation inductively coupled plasma
                      mass spectrometry (LA-ICP-MS) offers the capability to
                      quantify trace elements and isotopes within tissue sections
                      with a spatial resolution ranging about 10–100 μm.
                      Distribution analysis adds to clarifying basic questions of
                      biomedical research and enables bioaccumulation and
                      bioavailability studies for ecological and toxicological
                      risk assessment in humans, animals and plants. Major
                      application fields of mass spectrometry imaging (MSI) and
                      metallomics have been in brain and cancer research, animal
                      model validation, drug development and plant science. Here
                      we give an overview of latest achievements in methods and
                      applications. Recent improvements in ablation systems,
                      operation and cell design enabled progressively better
                      spatial resolutions down to 1 μm. Meanwhile, a body of
                      research has accumulated covering basic principles of the
                      element architecture in animals and plants that could
                      consistently be reproduced by several laboratories such as
                      the distribution of Fe, Cu, Zn in rodent brain. Several
                      studies investigated the distribution and delivery of
                      metallo-drugs in animals. Hyper-accumulating plants and
                      pollution indicator organisms have been the key topics in
                      environmental science. Increasingly, larger series of
                      samples are analyzed, may it be in the frame of comparisons
                      between intervention and control groups, of time kinetics or
                      of three-dimensional atlas approaches.},
      cin          = {ZEA-3 / INM-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ZEA-3-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {313 - Cancer risk factors and prevention (POF2-313)},
      pid          = {G:(DE-HGF)POF2-313},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000338713400001},
      doi          = {10.1016/j.aca.2014.04.048},
      url          = {https://juser.fz-juelich.de/record/201007},
}