%0 Journal Article
%A Goulas, Alexandros
%A Bastiani, Matteo
%A Bezgin, Gleb
%A Uylings, Harry B. M.
%A Roebroeck, Alard
%A Stiers, Peter
%T Comparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain
%J PLoS Computational Biology
%V 10
%N 3
%@ 1553-7358
%C San Francisco, Calif.
%I Public Library of Science
%M FZJ-2015-03556
%P e1003529 
%D 2014
%X The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000336509000040
%$ pmid:24676052
%R 10.1371/journal.pcbi.1003529
%U https://juser.fz-juelich.de/record/201251