Journal Article

FZJ-2015-03556

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain

Goulas, A. (Corresponding Author) ; Bastiani, M.FZJ* ; Bezgin, G. ; Uylings, H. B. M. ; Roebroeck, A. ; Stiers, P.

2014
Public Library of Science San Francisco, Calif.

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Please use a persistent id in citations: http://hdl.handle.net/2128/8720  doi:10.1371/journal.pcbi.1003529

Abstract: The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. JARA-BRAIN (JARA-BRAIN)

Research Program(s):

1. 332 - Imaging the Living Brain (POF2-332) (POF2-332)

Appears in the scientific report 2015

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Database coverage:
; ; ; ; BIOSIS Previews ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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