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000201251 1001_ $$0P:(DE-HGF)0$$aGoulas, Alexandros$$b0$$eCorresponding Author
000201251 245__ $$aComparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain
000201251 260__ $$aSan Francisco, Calif.$$bPublic Library of Science$$c2014
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000201251 520__ $$aThe macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.
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000201251 7001_ $$0P:(DE-Juel1)143661$$aBastiani, Matteo$$b1
000201251 7001_ $$0P:(DE-HGF)0$$aBezgin, Gleb$$b2
000201251 7001_ $$0P:(DE-HGF)0$$aUylings, Harry B. M.$$b3
000201251 7001_ $$0P:(DE-HGF)0$$aRoebroeck, Alard$$b4
000201251 7001_ $$0P:(DE-HGF)0$$aStiers, Peter$$b5
000201251 773__ $$0PERI:(DE-600)2193340-6$$a10.1371/journal.pcbi.1003529$$gVol. 10, no. 3, p. e1003529 -$$n3$$pe1003529 $$tPLoS Computational Biology$$v10$$x1553-7358$$y2014
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