TY  - JOUR
AU  - Goulas, Alexandros
AU  - Bastiani, Matteo
AU  - Bezgin, Gleb
AU  - Uylings, Harry B. M.
AU  - Roebroeck, Alard
AU  - Stiers, Peter
TI  - Comparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain
JO  - PLoS Computational Biology
VL  - 10
IS  - 3
SN  - 1553-7358
CY  - San Francisco, Calif.
PB  - Public Library of Science
M1  - FZJ-2015-03556
SP  - e1003529 
PY  - 2014
AB  - The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000336509000040
C6  - pmid:24676052
DO  - DOI:10.1371/journal.pcbi.1003529
UR  - https://juser.fz-juelich.de/record/201251
ER  -