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100 1 _ |a Goulas, Alexandros
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245 _ _ |a Comparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain
260 _ _ |a San Francisco, Calif.
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520 _ _ |a The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.
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700 1 _ |a Bastiani, Matteo
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700 1 _ |a Bezgin, Gleb
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700 1 _ |a Uylings, Harry B. M.
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700 1 _ |a Roebroeck, Alard
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700 1 _ |a Stiers, Peter
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773 _ _ |a 10.1371/journal.pcbi.1003529
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