TY  - JOUR
AU  - Chiriano, Gianpaolo
AU  - Sartini, Andrea
AU  - Mancini, Francesca
AU  - Andrisano, Vincenza
AU  - Bolognesi, Maria L.
AU  - Roberti, Marinella
AU  - Recanatini, Maurizio
AU  - Carloni, Paolo
AU  - Cavalli, Andrea
TI  - Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE-1 Inhibitors
JO  - Chemical biology and drug design
VL  - 77
IS  - 4
SN  - 1747-0277
CY  - Oxford
PB  - Wiley-Blackwell
M1  - FZJ-2015-03591
SP  - 268 - 271
PY  - 2011
AB  - In this letter, we report on the sequential application of two different in silico screening approaches combined with bioassays aimed at the identification of small organic molecules as potential BACE-1 inhibitors. Two hits endowed of micromolar inhibitory potency were selected, and the binding mode of the most potent compound was further characterized through docking simulations.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000288265200005
C6  - pmid:21244641
DO  - DOI:10.1111/j.1747-0285.2011.01087.x
UR  - https://juser.fz-juelich.de/record/201286
ER  -