Journal Article

FZJ-2015-03591

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE-1 Inhibitors

Chiriano, G. ; Sartini, A. ; Mancini, F. ; Andrisano, V. ; Bolognesi, M. L. ; Roberti, M. ; Recanatini, M. ; Carloni, P.FZJ* ; Cavalli, A. (Corresponding Author)

2011
Wiley-Blackwell Oxford

This record in other databases:      

Please use a persistent id in citations: doi:10.1111/j.1747-0285.2011.01087.x

Abstract: In this letter, we report on the sequential application of two different in silico screening approaches combined with bioassays aimed at the identification of small organic molecules as potential BACE-1 inhibitors. Two hits endowed of micromolar inhibitory potency were selected, and the binding mode of the most potent compound was further characterized through docking simulations.

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Contributing Institute(s):

1. GRS (GRS)
2. Computational Biomedicine (IAS-5)

Research Program(s):

1. 899 - ohne Topic (POF2-899) (POF2-899)

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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