TY  - JOUR
AU  - Sandal, Massimo
AU  - Duy, Tran Phuoc
AU  - Cona, Matteo
AU  - Zung, Hoang
AU  - Carloni, Paolo
AU  - Musiani, Francesco
AU  - Giorgetti, Alejandro
TI  - GOMoDo: A GPCRs Online Modeling and Docking Webserver
JO  - PLoS one
VL  - 8
IS  - 9
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - FZJ-2015-03610
SP  - e74092 -
PY  - 2013
AB  - G-protein coupled receptors (GPCRs) are a superfamily of cell signaling membrane proteins that include >750 members in the human genome alone. They are the largest family of drug targets. The vast diversity and relevance of GPCRs contrasts with the paucity of structures available: only 21 unique GPCR structures have been experimentally determined as of the beginning of 2013. User-friendly modeling and small molecule docking tools are thus in great demand. While both GPCR structural predictions and docking servers exist separately, with GOMoDo (GPCR Online Modeling and Docking), we provide a web server to seamlessly model GPCR structures and dock ligands to the models in a single consistent pipeline. GOMoDo can automatically perform template choice, homology modeling and either blind or information-driven docking by combining together proven, state of the art bioinformatic tools. The web server gives the user the possibility of guiding the whole procedure. The GOMoDo server is freely accessible at http://molsim.sci.univr.it/gomodo.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000324856500075
C6  - pmid:24058518
DO  - DOI:10.1371/journal.pone.0074092
UR  - https://juser.fz-juelich.de/record/201305
ER  -