Journal Article

FZJ-2015-03610

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png GOMoDo: A GPCRs Online Modeling and Docking Webserver

Sandal, M.GRS* ; Duy, T. P. ; Cona, M. ; Zung, H. ; Carloni, P.FZJ* ; Musiani, F. (Corresponding Author) ; Giorgetti, A. (Corresponding Author)

2013
PLoS Lawrence, Kan.

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/8786  doi:10.1371/journal.pone.0074092

Abstract: G-protein coupled receptors (GPCRs) are a superfamily of cell signaling membrane proteins that include >750 members in the human genome alone. They are the largest family of drug targets. The vast diversity and relevance of GPCRs contrasts with the paucity of structures available: only 21 unique GPCR structures have been experimentally determined as of the beginning of 2013. User-friendly modeling and small molecule docking tools are thus in great demand. While both GPCR structural predictions and docking servers exist separately, with GOMoDo (GPCR Online Modeling and Docking), we provide a web server to seamlessly model GPCR structures and dock ligands to the models in a single consistent pipeline. GOMoDo can automatically perform template choice, homology modeling and either blind or information-driven docking by combining together proven, state of the art bioinformatic tools. The web server gives the user the possibility of guiding the whole procedure. The GOMoDo server is freely accessible at http://molsim.sci.univr.it/gomodo.

---

Contributing Institute(s):

1. GRS (GRS)
2. Computational Biomedicine (IAS-5)

Research Program(s):

1. 899 - ohne Topic (POF2-899) (POF2-899)

---

Database coverage:
; ; ; ; BIOSIS Previews ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

---