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| 001 | 201376 | ||
| 005 | 20210129215734.0 | ||
| 024 | 7 | _ | |a 10.1111/j.1440-1789.2012.01322.x |2 doi |
| 024 | 7 | _ | |a 0919-6544 |2 ISSN |
| 024 | 7 | _ | |a 1440-1789 |2 ISSN |
| 024 | 7 | _ | |a WOS:000314472000004 |2 WOS |
| 037 | _ | _ | |a FZJ-2015-03671 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Claus, Helene L. |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a NG2 and NG2-positive cells delineate focal cerebral infarct demarcation in rats |
| 260 | _ | _ | |a Oxford [u.a.] |c 2013 |b Wiley-Blackwell |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1435122987_21687 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 520 | _ | _ | |a Focal cerebral ischemia induces cellular responses that may result in secondary tissue damage. We recently demonstrated multi-facetted spatial and temporal patterns of neuroinflammation by multimodal imaging. In the present study, we especially focus on the separation of vital and necrotic tissue, which enabled us to define a demarcation zone. Focal cerebral ischemia was induced via macrosphere embolization of the middle cerebral artery in Wistar rats. Subsequent cellular processes were investigated immunohistochemically from 3 to 56 days after onset of ischemia. We detected several infarct subareas: a necrotic infarct core and its margin adjacent to a nerve/glial antigen 2 (NG2)+ zone delineating it from a vital peri-infarct zone. Initially transition from necrotic to vital tissue was gradual; later on necrosis was precisely separated from vital tissue by a narrow NG2+ belt that was devoid of astrocytes, oligodendrocytes or neurons. Within this demarcation zone NG2+ cells associate with ionized calcium binding adaptor molecule 1 (Iba1) but not with GFAP, neuronal nuclear antigen (NeuN) or 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNPase). During further infarct maturation NG2 seemed to be positioned in the extracellular matrix (ECM) of the demarcation zone, whereas Iba1+ cells invaded the necrotic infarct core and GFAP+ cells built a gliotic containing belt between the lesion and NeuN+ unaffected tissue. Overall, our data suggested that NG2 proteoglycan expression and secretion hallmarked demarcation as a process that actively separated necrosis from vital tissue and therefore decisively impacts secondary neurodegeneration after ischemic stroke. |
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| 700 | 1 | _ | |a Walberer, Maureen |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Simard, Marie L. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Emig, Beata |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Muesken, Sophia M. |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Rueger, Maria A. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Fink, Gereon R. |0 P:(DE-Juel1)131720 |b 6 |
| 700 | 1 | _ | |a Schroeter, Michael |0 P:(DE-HGF)0 |b 7 |e Corresponding Author |
| 773 | _ | _ | |a 10.1111/j.1440-1789.2012.01322.x |g Vol. 33, no. 1, p. 30 - 38 |0 PERI:(DE-600)2008290-3 |n 1 |p 30 - 38 |t Neuropathology |v 33 |y 2013 |x 0919-6544 |
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| 910 | 1 | _ | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 6 |6 P:(DE-Juel1)131720 |
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