Journal Article

FZJ-2015-04434

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Callyspongiolide, a Cytotoxic Macrolide from the Marine Sponge Callyspongia sp.

Pham, C.-D. ; Hartmann, R.FZJ* ; Böhler, P. ; Stork, B. ; Wesselborg, S. ; Lin, W. ; Lai, D. (Corresponding Author) ; Proksch, P. (Corresponding Author)

2014
ACS Washington, DC

This record in other databases:      

Please use a persistent id in citations: doi:10.1021/ol403241v

Abstract: A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.

---

Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 452 - Structural Biology (POF2-452) (POF2-452)

Appears in the scientific report 2015

---

Database coverage:
; BIOSIS Previews ; Current Contents - Physical, Chemical and Earth Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---