001     202145
005     20210129220043.0
024 7 _ |a 10.1021/ol403241v
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082 _ _ |a 540
100 1 _ |a Pham, Cong-Dat
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245 _ _ |a Callyspongiolide, a Cytotoxic Macrolide from the Marine Sponge Callyspongia sp.
260 _ _ |a Washington, DC
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336 7 _ |a Journal Article
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520 _ _ |a A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.
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700 1 _ |a Hartmann, Rudolf
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700 1 _ |a Böhler, Philip
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700 1 _ |a Stork, Björn
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700 1 _ |a Wesselborg, Sebastian
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700 1 _ |a Lin, Wenhan
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700 1 _ |a Lai, Daowan
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700 1 _ |a Proksch, Peter
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773 _ _ |a 10.1021/ol403241v
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