%0 Journal Article
%A Mangiapia, G.
%A D'Errico, G.
%A Simeone, L.
%A Irace, C.
%A Radulescu, A.
%A DiPascale, A.
%A Colonna, A.
%A Montesarchio, D.
%A Paduano, L.
%T Ruthenium-based complex nanocarriers for cancer therapy
%J Biomaterials
%V 33
%@ 0142-9612
%C Amsterdam [u.a.]
%I Elsevier Science
%M PreJuSER-20252
%P 3770 - 3782
%D 2012
%Z This work was supported by MIUR (PRIN 2008-prot. 20087K9A2J). The authors thank the Forschungszentrum Julich for provision of beam time. SANS experiments were supported by the European Commission, NMI3 contract RII3-CT-2003-505925.
%X A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.
%K Animals
%K Antineoplastic Agents: administration & dosage
%K Antineoplastic Agents: chemistry
%K Cell Line, Tumor
%K Cell Survival: drug effects
%K Drug Carriers
%K Drug Stability
%K Humans
%K Liposomes
%K Materials Testing
%K Microscopy, Fluorescence
%K Nanoparticles: administration & dosage
%K Nanoparticles: chemistry
%K Neoplasms: drug therapy
%K Organometallic Compounds: administration & dosage
%K Organometallic Compounds: chemistry
%K Rats
%K Ruthenium: administration & dosage
%K Ruthenium: chemistry
%K Antineoplastic Agents (NLM Chemicals)
%K Drug Carriers (NLM Chemicals)
%K Liposomes (NLM Chemicals)
%K Organometallic Compounds (NLM Chemicals)
%K Ruthenium (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22357152
%U <Go to ISI:>//WOS:000302425400015
%R 10.1016/j.biomaterials.2012.01.057
%U https://juser.fz-juelich.de/record/20252