Journal Article

PreJuSER-20252

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ruthenium-based complex nanocarriers for cancer therapy

Mangiapia, G. ; D'Errico, G. ; Simeone, L. ; Irace, C. ; Radulescu, A.FZJ* ; DiPascale, A. ; Colonna, A. ; Montesarchio, D. ; Paduano, L.

2012
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.biomaterials.2012.01.057

Abstract: A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.

Keyword(s): Animals (MeSH) ; Antineoplastic Agents: administration & dosage (MeSH) ; Antineoplastic Agents: chemistry (MeSH) ; Cell Line, Tumor (MeSH) ; Cell Survival: drug effects (MeSH) ; Drug Carriers (MeSH) ; Drug Stability (MeSH) ; Humans (MeSH) ; Liposomes (MeSH) ; Materials Testing (MeSH) ; Microscopy, Fluorescence (MeSH) ; Nanoparticles: administration & dosage (MeSH) ; Nanoparticles: chemistry (MeSH) ; Neoplasms: drug therapy (MeSH) ; Organometallic Compounds: administration & dosage (MeSH) ; Organometallic Compounds: chemistry (MeSH) ; Rats (MeSH) ; Ruthenium: administration & dosage (MeSH) ; Ruthenium: chemistry (MeSH) ; Health and Life (1st) ; Health and Life (1st) ; Biology (2nd) ; Antineoplastic Agents ; Drug Carriers ; Liposomes ; Organometallic Compounds ; Ruthenium ; J ; Ruthenium-based complexes (auto) ; Antineoplastic agents (auto) ; Nanoaggregates (auto) ; Anti-proliferative activity (auto)

Note: This work was supported by MIUR (PRIN 2008-prot. 20087K9A2J). The authors thank the Forschungszentrum Julich for provision of beam time. SANS experiments were supported by the European Commission, NMI3 contract RII3-CT-2003-505925.

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Contributing Institute(s):

1. Neutronenstreuung (ICS-1)
2. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
3. Neutronenstreuung (JCNS-1)

Research Program(s):

1. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (FUEK505) (FUEK505)
2. 544 - In-house Research with PNI (POF2-544) (POF2-544)

Experiment(s):

1. KWS-2: Small angle scattering diffractometer (NL3ao)

Appears in the scientific report 2012

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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