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000020252 0247_ $$2DOI$$a10.1016/j.biomaterials.2012.01.057
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000020252 084__ $$2WoS$$aEngineering, Biomedical
000020252 084__ $$2WoS$$aMaterials Science, Biomaterials
000020252 1001_ $$0P:(DE-HGF)0$$aMangiapia, G.$$b0
000020252 245__ $$aRuthenium-based complex nanocarriers for cancer therapy
000020252 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2012
000020252 300__ $$a3770 - 3782
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000020252 440_0 $$0863$$aBiomaterials$$v33$$x0142-9612$$y14
000020252 500__ $$aThis work was supported by MIUR (PRIN 2008-prot. 20087K9A2J). The authors thank the Forschungszentrum Julich for provision of beam time. SANS experiments were supported by the European Commission, NMI3 contract RII3-CT-2003-505925.
000020252 520__ $$aA new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.
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000020252 65320 $$2Author$$aRuthenium-based complexes
000020252 65320 $$2Author$$aAntineoplastic agents
000020252 65320 $$2Author$$aNanoaggregates
000020252 65320 $$2Author$$aAnti-proliferative activity
000020252 650_2 $$2MeSH$$aAnimals
000020252 650_2 $$2MeSH$$aAntineoplastic Agents: administration & dosage
000020252 650_2 $$2MeSH$$aAntineoplastic Agents: chemistry
000020252 650_2 $$2MeSH$$aCell Line, Tumor
000020252 650_2 $$2MeSH$$aCell Survival: drug effects
000020252 650_2 $$2MeSH$$aDrug Carriers
000020252 650_2 $$2MeSH$$aDrug Stability
000020252 650_2 $$2MeSH$$aHumans
000020252 650_2 $$2MeSH$$aLiposomes
000020252 650_2 $$2MeSH$$aMaterials Testing
000020252 650_2 $$2MeSH$$aMicroscopy, Fluorescence
000020252 650_2 $$2MeSH$$aNanoparticles: administration & dosage
000020252 650_2 $$2MeSH$$aNanoparticles: chemistry
000020252 650_2 $$2MeSH$$aNeoplasms: drug therapy
000020252 650_2 $$2MeSH$$aOrganometallic Compounds: administration & dosage
000020252 650_2 $$2MeSH$$aOrganometallic Compounds: chemistry
000020252 650_2 $$2MeSH$$aRats
000020252 650_2 $$2MeSH$$aRuthenium: administration & dosage
000020252 650_2 $$2MeSH$$aRuthenium: chemistry
000020252 650_7 $$00$$2NLM Chemicals$$aAntineoplastic Agents
000020252 650_7 $$00$$2NLM Chemicals$$aDrug Carriers
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000020252 7001_ $$0P:(DE-HGF)0$$aD'Errico, G.$$b1
000020252 7001_ $$0P:(DE-HGF)0$$aSimeone, L.$$b2
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