TY  - JOUR
AU  - Mangiapia, G.
AU  - D'Errico, G.
AU  - Simeone, L.
AU  - Irace, C.
AU  - Radulescu, A.
AU  - DiPascale, A.
AU  - Colonna, A.
AU  - Montesarchio, D.
AU  - Paduano, L.
TI  - Ruthenium-based complex nanocarriers for cancer therapy
JO  - Biomaterials
VL  - 33
SN  - 0142-9612
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-20252
SP  - 3770 - 3782
PY  - 2012
N1  - This work was supported by MIUR (PRIN 2008-prot. 20087K9A2J). The authors thank the Forschungszentrum Julich for provision of beam time. SANS experiments were supported by the European Commission, NMI3 contract RII3-CT-2003-505925.
AB  - A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.
KW  - Animals
KW  - Antineoplastic Agents: administration & dosage
KW  - Antineoplastic Agents: chemistry
KW  - Cell Line, Tumor
KW  - Cell Survival: drug effects
KW  - Drug Carriers
KW  - Drug Stability
KW  - Humans
KW  - Liposomes
KW  - Materials Testing
KW  - Microscopy, Fluorescence
KW  - Nanoparticles: administration & dosage
KW  - Nanoparticles: chemistry
KW  - Neoplasms: drug therapy
KW  - Organometallic Compounds: administration & dosage
KW  - Organometallic Compounds: chemistry
KW  - Rats
KW  - Ruthenium: administration & dosage
KW  - Ruthenium: chemistry
KW  - Antineoplastic Agents (NLM Chemicals)
KW  - Drug Carriers (NLM Chemicals)
KW  - Liposomes (NLM Chemicals)
KW  - Organometallic Compounds (NLM Chemicals)
KW  - Ruthenium (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22357152
UR  - <Go to ISI:>//WOS:000302425400015
DO  - DOI:10.1016/j.biomaterials.2012.01.057
UR  - https://juser.fz-juelich.de/record/20252
ER  -