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@ARTICLE{Mangiapia:20252,
      author       = {Mangiapia, G. and D'Errico, G. and Simeone, L. and Irace,
                      C. and Radulescu, A. and DiPascale, A. and Colonna, A. and
                      Montesarchio, D. and Paduano, L.},
      title        = {{R}uthenium-based complex nanocarriers for cancer therapy},
      journal      = {Biomaterials},
      volume       = {33},
      issn         = {0142-9612},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-20252},
      pages        = {3770 - 3782},
      year         = {2012},
      note         = {This work was supported by MIUR (PRIN 2008-prot.
                      20087K9A2J). The authors thank the Forschungszentrum Julich
                      for provision of beam time. SANS experiments were supported
                      by the European Commission, NMI3 contract
                      RII3-CT-2003-505925.},
      abstract     = {A new organometallic ruthenium complex, named AziRu, along
                      with three amphiphilic nucleoside-based ruthenium complexes,
                      ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their
                      skeleton, have been synthesized, stabilized in POPC
                      phospholipid formulations and studied for their
                      antineoplastic activity. Self-aggregation behavior of these
                      complexes was investigated, showing that the three
                      synthesized AziRu derivatives able to form liposomes and,
                      under specific conditions, elongated micelles. The
                      formulations prepared in POPC proved to be stable for months
                      and showed high in vitro antiproliferative activity. The
                      here described results open new scenarios in the design of
                      innovative transition metal-based supramolecular systems for
                      anticancer drugs vectorization.},
      keywords     = {Animals / Antineoplastic Agents: administration $\&$ dosage
                      / Antineoplastic Agents: chemistry / Cell Line, Tumor / Cell
                      Survival: drug effects / Drug Carriers / Drug Stability /
                      Humans / Liposomes / Materials Testing / Microscopy,
                      Fluorescence / Nanoparticles: administration $\&$ dosage /
                      Nanoparticles: chemistry / Neoplasms: drug therapy /
                      Organometallic Compounds: administration $\&$ dosage /
                      Organometallic Compounds: chemistry / Rats / Ruthenium:
                      administration $\&$ dosage / Ruthenium: chemistry /
                      Antineoplastic Agents (NLM Chemicals) / Drug Carriers (NLM
                      Chemicals) / Liposomes (NLM Chemicals) / Organometallic
                      Compounds (NLM Chemicals) / Ruthenium (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ICS-1 / JCNS (München) ; Jülich Centre for Neutron
                      Science JCNS (München) ; JCNS-FRM-II / JCNS-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-1-20110106 /
                      I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung (FUEK505) / 544 - In-house Research
                      with PNI (POF2-544)},
      pid          = {G:(DE-Juel1)FUEK505 / G:(DE-HGF)POF2-544},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      shelfmark    = {Engineering, Biomedical / Materials Science, Biomaterials},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22357152},
      UT           = {WOS:000302425400015},
      doi          = {10.1016/j.biomaterials.2012.01.057},
      url          = {https://juser.fz-juelich.de/record/20252},
}