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|a Materials Science, Biomaterials
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|a Mangiapia, G.
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245 _ _ |a Ruthenium-based complex nanocarriers for cancer therapy
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2012
300 _ _ |a 3770 - 3782
336 7 _ |a Journal Article
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440 _ 0 |0 863
|a Biomaterials
|v 33
|x 0142-9612
|y 14
500 _ _ |a This work was supported by MIUR (PRIN 2008-prot. 20087K9A2J). The authors thank the Forschungszentrum Julich for provision of beam time. SANS experiments were supported by the European Commission, NMI3 contract RII3-CT-2003-505925.
520 _ _ |a A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.
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650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Antineoplastic Agents: administration & dosage
650 _ 2 |2 MeSH
|a Antineoplastic Agents: chemistry
650 _ 2 |2 MeSH
|a Cell Line, Tumor
650 _ 2 |2 MeSH
|a Cell Survival: drug effects
650 _ 2 |2 MeSH
|a Drug Carriers
650 _ 2 |2 MeSH
|a Drug Stability
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Liposomes
650 _ 2 |2 MeSH
|a Materials Testing
650 _ 2 |2 MeSH
|a Microscopy, Fluorescence
650 _ 2 |2 MeSH
|a Nanoparticles: administration & dosage
650 _ 2 |2 MeSH
|a Nanoparticles: chemistry
650 _ 2 |2 MeSH
|a Neoplasms: drug therapy
650 _ 2 |2 MeSH
|a Organometallic Compounds: administration & dosage
650 _ 2 |2 MeSH
|a Organometallic Compounds: chemistry
650 _ 2 |2 MeSH
|a Rats
650 _ 2 |2 MeSH
|a Ruthenium: administration & dosage
650 _ 2 |2 MeSH
|a Ruthenium: chemistry
650 _ 7 |0 0
|2 NLM Chemicals
|a Antineoplastic Agents
650 _ 7 |0 0
|2 NLM Chemicals
|a Drug Carriers
650 _ 7 |0 0
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|a Liposomes
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|a Ruthenium-based complexes
653 2 0 |2 Author
|a Antineoplastic agents
653 2 0 |2 Author
|a Nanoaggregates
653 2 0 |2 Author
|a Anti-proliferative activity
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