Journal Article

FZJ-2015-04887

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The effect of composition on Diffusion of macromolecules in a crowded environment

Kondrat, S. (Corresponding author)FZJ* ; Zimmermann, O.FZJ* ; Wiechert, W.FZJ* ; Lieres, E. v.

2015
IOP Publ. Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1088/1478-3975/12/4/046003

Abstract: We study diffusion of macromolecules in a crowded cytoplasm-like environment, focusing on its dependence on composition and its crossover to the anomalous subdiffusion. The crossover and the diffusion itself depend on both the volume fraction and the relative concentration of macromolecules. In accordance with previous theoretical and experimental studies, diffusion slows down when the volume fraction increases. Contrary to expectations, however, the diffusion is also strongly dependent on the molecular composition. The crossover time decreases and diffusion slows down when the smaller macromolecules start to dominate. Interestingly, diffusion is faster in a cytoplasm-like (more polydisperse) system than it is in a two-component system, at comparable packing fractions, or even when the cytoplasm packing fraction is larger.

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Contributing Institute(s):

1. Biotechnologie (IBG-1)
2. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 511 - Computational Science and Mathematical Methods (POF3-511) (POF3-511)
2. 581 - Biotechnology (POF3-581) (POF3-581)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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