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000203229 1001_ $$0P:(DE-Juel1)156284$$aChen, La$$b0$$ufzj
000203229 245__ $$aCharacterization of the mechanical properties of HL-1 cardiomyocytes with high throughput magnetic tweezers
000203229 260__ $$aMelville, NY$$bAmerican Inst. of Physics$$c2015
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000203229 520__ $$aWe characterized the mechanical properties of cardiomyocyte-like HL-1 cells using our recently developed multi-pole magnetic tweezers. With the optimized design, both high force and high throughput are achieved at the same time. Force up to 100 pN can be applied on a 1 μm diameter superparamagnetic bead in a workspace with 60 μm radius, which is encircled symmetrically by 3 sharp magnetic tips. By adjusting the coil currents, both the strength and direction of force can be controlled. The result shows that both viscosity and shear elastic modulus of HL-1 cells exhibit an approximately log-normal distribution. The cells became stiffer as they matured, consistent with a transition from proliferating cells to contractile muscle tissue. Moreover, the mechanical properties of HL-1 cells show high heterogeneity, which agrees well with their physiological structure.
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000203229 7001_ $$0P:(DE-Juel1)128705$$aMaybeck, Vanessa$$b1$$ufzj
000203229 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b2$$ufzj
000203229 7001_ $$00000-0002-7526-9894$$aKrause, Hans-Joachim$$b3$$eCorresponding author
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